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Melatonin modulates γ-aminobutyric acidA receptor-mediated currents on isolated carp retinal neurons
- Source :
- Neuroscience Letters. 301:49-53
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- Modulation by melatonin of gamma-aminobutyric acid(A) (GABA(A)) receptor-mediated responses was studied in bipolar and amacrine-like cells acutely isolated from carp retina, using the whole-cell patch-clamp technique. Melatonin of 1 mM accelerated desensitization of the GABA(A) receptors at both bipolar and amacrine-like cells. In addition, 1 mM melatonin hardly changed the GABA(A) receptor-mediated response amplitude of bipolar cells, while it increased or decreased that of amacrine-like cells, depending on the concentration of GABA applied. These modulatory effects, which can not be blocked by luzindole, a melatonin receptor antagonist, may be due to the allosteric action caused by melatonin bound to a site of the GABA(A) receptors.
- Subjects :
- medicine.medical_specialty
Biology
Melatonin receptor
gamma-Aminobutyric acid
Melatonin
Desensitization (telecommunications)
Retinal Rod Photoreceptor Cells
Goldfish
Internal medicine
medicine
Animals
Receptor
gamma-Aminobutyric Acid
Retina
Dose-Response Relationship, Drug
General Neuroscience
Antagonist
Receptors, GABA-A
Endocrinology
medicine.anatomical_structure
Anticonvulsants
sense organs
Luzindole
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 301
- Database :
- OpenAIRE
- Journal :
- Neuroscience Letters
- Accession number :
- edsair.doi.dedup.....69b8c767a785e4b1f4671f2ee23dc37a