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Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Infection on Pregnant Women and Their Infants
- Source :
- Archives of Pathology & Laboratory Medicine. 144:1217-1222
- Publication Year :
- 2020
- Publisher :
- Archives of Pathology and Laboratory Medicine, 2020.
-
Abstract
- Context.— The pandemic of a novel coronavirus, termed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created an unprecedented global health burden. Objective.— To investigate the effect of the SARS-CoV-2 infection on maternal, fetal, and neonatal morbidity and other poor obstetrical outcomes. Design.— All suspected cases of pregnant women with coronavirus disease 2019 (COVID-19) admitted into one center in Wuhan from January 20 to March 19, 2020, were included. Detailed clinical data of those pregnancies with COVID-19 were retrospectively collected and analyzed. Results.— Twenty-seven pregnant women (4 early pregnancies included) with laboratory or clinically confirmed SARS-CoV-2 infection and 24 neonates born to the 23 women in late pregnancy were analyzed. On admission, 46.2% (13 of 27) of the patients had symptoms, including fever (11 of 27), cough (9 of 27), and vomiting (1 of 27). Decreased total lymphocytes count was observed in 81.5% (22 of 27) of patients. Twenty-six patients showed typical viral pneumonia by chest computed tomography scan, whereas 1 patient confirmed with COVID-19 infection showed no abnormality on chest computed tomography. One mother developed severe pneumonia 3 days after her delivery. No maternal or perinatal death occurred. Moreover, 1 early preterm newborn born to a mother with the complication of premature rupture of fetal membranes, highly suspected to have SARS-CoV-2 infection, was SARS-CoV-2 negative after repeated real-time reverse transcriptase polymerase chain reaction testing. Statistical differences were observed between the groups of women in early and late pregnancy with COVID-19 in the occurrence of lymphopenia and thrombocytopenia. Conclusions.— No major complications were reported among the studied cohort, though 1 serious case and 1 perinatal infection were observed. Much effort should be made to reduce the pathogenic effect of COVID-19 infection in pregnancies.
- Subjects :
- Adult
China
Pediatrics
medicine.medical_specialty
Pneumonia, Viral
medicine.disease_cause
Pathology and Forensic Medicine
Betacoronavirus
Young Adult
03 medical and health sciences
0302 clinical medicine
Pregnancy
medicine
Humans
030212 general & internal medicine
Pregnancy Complications, Infectious
Pandemics
Retrospective Studies
Coronavirus
030219 obstetrics & reproductive medicine
SARS-CoV-2
business.industry
Infant, Newborn
Pregnancy Outcome
COVID-19
Retrospective cohort study
General Medicine
medicine.disease
Medical Laboratory Technology
Pneumonia
Viral pneumonia
Cohort
Vomiting
Female
medicine.symptom
Coronavirus Infections
Complication
business
Subjects
Details
- ISSN :
- 15432165 and 00039985
- Volume :
- 144
- Database :
- OpenAIRE
- Journal :
- Archives of Pathology & Laboratory Medicine
- Accession number :
- edsair.doi.dedup.....69c54ac47ecbee6bf0825fd13a8b52d4