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The structural brain correlates of callous-unemotional traits in incarcerated male adolescents
- Source :
- NeuroImage : Clinical, NeuroImage: Clinical, Vol 22, Iss, Pp-(2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Youth with severe conduct problems impose a significant cost on society by engaging in high levels of antisocial and aggressive behavior. Within this group, adolescents with high levels of callous- unemotional traits have been found to exhibit more severe and persistent patterns of antisocial behavior than youth with severe conduct problems but normative levels of callous-unemotional traits. Existing neuroimaging studies, along with theoretical accounts of psychopathology, suggest that dysfunction within the paralimbic cortex and limbic system may underlie elevated levels of callous-unemotional traits. The present study examines this hypothesis by investigating gray matter correlates associated with callous-unemotional traits. A sample of incarcerated male adolescents (N = 269), were assessed using voxel-based morphometry. Callous-unemotional traits were assessed using the Inventory of Callous-Unemotional traits (Frick 2004). Total callous-unemotional traits were negatively correlated with anterior temporal lobe gray matter volume (GMV). Callous traits in particular exhibited a reliable negative correlation with gray matter volume in nearly every paralimbic brain region examined. Uncaring traits were positively correlated with GMV in the orbitofrontal and anterior cingulate cortices. These findings demonstrate specific neural features within the paralimbic cortex and limbic system that accompany elevated callous-unemotional traits and serves to expand our understanding of pathophysiological mechanisms that may give rise to severe conduct problems in youth.<br />Highlights • Total callous-unemotional traits were negatively correlated with anterior temporal lobe gray matter volume (GMV). • Callous traits negatively correlated with GMV in nearly every paralimbic regions examined. • Uncaring traits were positively correlated with GMV in the orbitofrontal and anterior cingulate cortices.
- Subjects :
- Male
Paralimbic cortex
lcsh:RC346-429
0302 clinical medicine
Limbic system
CU, callous-unemotional
aTL, anterior temporal lobe
ICU, Inventory of Callous-Unemotional Traits
ACC, anterior cingulate
05 social sciences
Brain
Regular Article
Antisocial Personality Disorder
Magnetic Resonance Imaging
Aggression
aINS, anterior insula
Brain region
medicine.anatomical_structure
Neurology
fMRI, functional magnetic resonance imaging
GMV, gray matter volume
Conduct disorder
lcsh:R858-859.7
PHG, parahippocampal gyrus
Psychology
Clinical psychology
Psychopathology
Conduct Disorder
Adolescent
Cognitive Neuroscience
Gray matter volume
pSTS, posterior superior temporal sulcus
lcsh:Computer applications to medicine. Medical informatics
050105 experimental psychology
03 medical and health sciences
Neuroimaging
medicine
vSTR, ventral striatum
Humans
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
lcsh:Neurology. Diseases of the nervous system
GMD, gray matter density
Paralimbic system dysfunction
Callous unemotional
LCUs, youth with conduct problems who exhibit normative levels of Callous-Unemotional traits
Prisoners
sMRI, structural magnetic resonance imaging
Voxel-based morphometry
mOFC, medial orbitofrontal cortex
medicine.disease
HCUs, youth with conduct problems who exhibit elevated levels of callous-unemotional traits
Callous-unemotional traits
PCC, posterior cingulate
Neurology (clinical)
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 22131582
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- NeuroImage: Clinical
- Accession number :
- edsair.doi.dedup.....69c906d88113e73dfd7427409e5d35d9