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Caseatardies A-K, eleven undescribed clerodane diterpenoids isolated from Casearia tardieuae and their anti-inflammatory activity

Caseatardies A-K, eleven undescribed clerodane diterpenoids isolated from Casearia tardieuae and their anti-inflammatory activity

Authors :
Jing-Jing Zhang
Peng-Yun Yang
Quan Fu
Qiong Wei
De-Wen Bi
Xue-Wen Wu
Bin Cheng
Rui-Han Zhang
Xiao-Chang Dai
Xing-Jie Zhang
Xiao-Li Li
Wei-Lie Xiao
Source :
Fitoterapia. 163:105328
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

A phytochemical investigation to obtain bioactive substances as lead compounds or agents for anti-inflammatory led to the obtainment of eleven previously undescribed clerodane diterpenoids, named caseatardies A-K (1-11), and four known clerodane diterpenoids (12-15) from the twigs and leaves of Casearia tardieuae. The structural elucidation of these clerodane diterpenoids was based on 1D and 2D-NMR spectroscopy (COSY, HSQC, HMBC and ROESY) as well as high resolution mass spectrometry (HR-ESI-MS). The relative configurations were defined by ROESY correlations. The anti-inflammatory activity of all the isolated compounds was screened and compound 15 decreased LDH level in a dose-dependent manner, showing IC

Details

ISSN :
0367326X
Volume :
163
Database :
OpenAIRE
Journal :
Fitoterapia
Accession number :
edsair.doi.dedup.....69da430957f96955916e0d0d9c494ef4
Full Text :
https://doi.org/10.1016/j.fitote.2022.105328