CaMKII orchestrates endoplasmic reticulum stress and apoptosis in doxorubicin-induced cardiotoxicity by regulating the IRE1α/XBP1s pathway

Authors :: Lingheng Kong
Yimeng Zhang
Jiayi Ning
Chennian Xu
Zhenyi Wang
Jian Yang
Lifang Yang
Source :: Journal of cellular and molecular medicine. 26(20)
Publication Year :: 2022
Abstract: Doxorubicin (Dox), an anthracycline antibiotic with potent antitumor effects, has limited clinical applications due to cumulative cardiotoxicity. Ca

Subjects :: X-Box Binding Protein 1
Apoptosis
Cell Biology
Protein Serine-Threonine Kinases
Endoplasmic Reticulum Stress
Cardiotoxicity
Anti-Bacterial Agents
Thrombospondin 1
Doxorubicin
Endoribonucleases
Molecular Medicine
Humans
Myocytes, Cardiac
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Inositol

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