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Amphotericin B lipid complex (ABLC) for the treatment of confirmed or presumed fungal infections in immunocompromised patients with hematologic malignancies
- Source :
- Bone Marrow Transplantation. 20:39-43
- Publication Year :
- 1997
- Publisher :
- Springer Science and Business Media LLC, 1997.
-
Abstract
- Sixty-four adult patients (median age 43) with hematologic malignancies who were immunocompromised after allogeneic (n = 23) or autologous (n = 9) blood/marrow transplantation, or chemotherapy (n = 32) received 68 courses of amphotericin B lipid complex (ABLC, Abelcet) at the daily dose of 5 mg/kg for presumed (n = 52) or proven (n = 16) fungal infection. The major indications for ABLC were failure of previous antifungal therapy and/or renal dysfunction. Fifty-three treatment courses in 49 patients comprising 4-58 doses (median 10) were considered evaluable. Fourteen courses administered for confirmed infections resulted in nine complete and one partial responses, and four failures (71% response). Thirty-nine empiric courses resulted in 18 complete and six partial responses, and 14 failures (64% response). The overall response rate was 66%. Five of seven evaluable patients with aspergillus pneumonia responded. Response rates were comparable for chemotherapy, autograft and allograft recipients. The change in serum creatinine from the beginning to the end of therapy was -284 to +277 mumol/l (median +24). The creatinine doubled during seven evaluable courses of therapy, five of which were associated with concomitant nephrotoxic therapy. Nephrotoxicity was comparable for transplant and chemotherapy patients. Renal dysfunction necessitated discontinuation of ABLC in only four patients. These data suggest that ABLC is effective in presumed or confirmed fungal infections in immunocompromised patients after transplantation or chemotherapy.
- Subjects :
- Adult
Male
medicine.medical_specialty
Antifungal Agents
Adolescent
medicine.medical_treatment
Aspergillosis
Transplantation, Autologous
Gastroenterology
Nephrotoxicity
Immunocompromised Host
Amphotericin B
Internal medicine
medicine
Humans
Transplantation, Homologous
Mycosis
Aged
Bone Marrow Transplantation
Transplantation
Chemotherapy
business.industry
Phosphatidylglycerols
Immunosuppression
Hematology
Middle Aged
medicine.disease
Surgery
Drug Combinations
Mycoses
Hematologic Neoplasms
Concomitant
Phosphatidylcholines
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 14765365 and 02683369
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Bone Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....69ffaa1b0072abd47b452efb366973cd