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Extracellular ascorbate modulates glutamate dynamics: role of behavioral activation
Extracellular ascorbate modulates glutamate dynamics: role of behavioral activation
- Source :
- BMC Neuroscience, BMC Neuroscience, Vol 8, Iss 1, p 32 (2007)
- Publication Year :
- 2006
-
Abstract
- Background A physiological increase in extracellular ascorbate (AA), an antioxidant vitamin found throughout the striatum, elevates extracellular glutamate (GLU). To determine the role of behavioral arousal in this interaction, microdialysis was used to measure striatal GLU efflux in rats tested in either a lights-off or lights-on condition while reverse dialysis either maintained the concentration of AA at 250 μM or increased it to 1000 μM to approximate endogenous changes. Results When lights were off, both locomotion and GLU increased regardless of AA dose. In contrast, animals in the lights-on condition were behaviorally inactive, and infusion of 1000, but not 250, μM AA significantly increased extracellular GLU. Interestingly, when ambient light returned to the lights-off group, 1000 μM prolonged the GLU increase relative to the 250 μM group. Conclusion Our results not only support evidence that elevated striatal AA increases extracellular GLU but also indicate that this effect depends on behavioral state and the corresponding level of endogenous GLU release.
- Subjects :
- Vitamin
Male
medicine.medical_specialty
Microdialysis
Antioxidant
medicine.medical_treatment
Glutamic Acid
Endogeny
Striatum
Ascorbic Acid
lcsh:RC321-571
Rats, Sprague-Dawley
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Extracellular
Animals
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
030304 developmental biology
0303 health sciences
Behavior, Animal
Chemistry
General Neuroscience
lcsh:QP351-495
Glutamate receptor
Corpus Striatum
Rats
Endocrinology
lcsh:Neurophysiology and neuropsychology
Efflux
Arousal
030217 neurology & neurosurgery
Locomotion
Research Article
Subjects
Details
- ISSN :
- 14712202
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- BMC neuroscience
- Accession number :
- edsair.doi.dedup.....6a2537aeef8024bdd1e1fc48313016f7