Back to Search
Start Over
Modeling Cancer with Flies and Fish
- Source :
- Dev Cell
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Cancer has joined heart disease as the leading source of mortality in the US. In an era of organoids, patient-derived xenografts, and organs on a chip, model organisms continue to thrive with a combination of powerful genetic tools, rapid pace of discovery, and affordability. Model organisms enable the analysis of both the tumor and its associated microenvironment, aspects that are particularly relevant to our understanding of metastasis and drug resistance. In this Perspective, we explore some of the strengths of fruit flies and zebrafish for addressing fundamental cancer questions and how these two organisms can contribute to identifying promising therapeutic candidates.
- Subjects :
- ved/biology.organism_classification_rank.species
Computational biology
Biology
Organ-on-a-chip
Article
General Biochemistry, Genetics and Molecular Biology
Metastasis
03 medical and health sciences
0302 clinical medicine
Neoplasms
Tumor Microenvironment
medicine
Animals
Humans
Model organism
Molecular Biology
Zebrafish
030304 developmental biology
0303 health sciences
ved/biology
Extramural
Cancer
Cell Biology
medicine.disease
biology.organism_classification
Organoids
Disease Models, Animal
Drosophila melanogaster
Fish
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- ISSN :
- 15345807
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Developmental Cell
- Accession number :
- edsair.doi.dedup.....6a4ebb9886584ca0043be03f6e0c33b3