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Exaggerated Cardiovascular Stress Responses and Impaired β-Adrenergic–Mediated Pressor Recovery in Obese Zucker Rats
- Source :
- Hypertension. 48:1109-1115
- Publication Year :
- 2006
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2006.
-
Abstract
- Clinical studies have demonstrated that the pressor response to acute stress is larger in obese versus lean individuals. We therefore tested the hypotheses that the pressor response to behavioral stress is greater in obese (OZRs) versus lean Zucker rats (LZRs) and that reduced β-adrenergic–mediated vasodilation contributes to the enhanced pressor response. Animals were restrained and subjected to acute pulsatile air jet stress (3 minutes), followed by a poststress period of 20 minutes; β-adrenergic blockade was achieved with propranolol (5 mg/kg, IV) given 15 minutes before the start of air jet stress. Mean arterial pressure (MAP) was continuously monitored by telemetry. Untreated OZRs responded with a greater integrated pressor response (area under the curve [AUC]) to acute stress (41.2±6.1 versus 21.2±3.3 mm Hg×3 minutes, OZR versus LZR; P P
- Subjects :
- Male
medicine.medical_specialty
Cardiac output
Mean arterial pressure
Pulsatile flow
Blood Pressure
Vasodilation
Propranolol
Internal medicine
Isoprenaline
Receptors, Adrenergic, beta
Internal Medicine
medicine
Animals
Obesity
business.industry
Area under the curve
Recovery of Function
Rats
Rats, Zucker
Disease Models, Animal
Endocrinology
Blood pressure
business
Stress, Psychological
medicine.drug
Subjects
Details
- ISSN :
- 15244563 and 0194911X
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Hypertension
- Accession number :
- edsair.doi.dedup.....6a607aa864e808a6eb4b5d19a4887547