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A study of urinary myo-inositol as a sensitive marker of glucose intolerance
- Source :
- Clinica chimica acta; international journal of clinical chemistry. 344(1-2)
- Publication Year :
- 2003
-
Abstract
- We assessed the possibility of using myo-inositol as a marker of glucose intolerance.We measured urinary myo-inositol enzymatically before and 2 h after a 75-g oral glucose tolerance test in 564 volunteers, who were divided into four groups [normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes mellitus (DM)]. Furthermore, we classified NGT into NGT-A (2-h blood glucose120 mg/dl and 2-h glucosuria50 mg/dl) and NGT-B (remaining NGT subjects). We then compared deltamyo-inositol (myo-inositol/creatinine ratio: 2-h after glucose load--before load) of each group to investigate the relationship between glucose intolerance and deltamyo-inositol.The glucose tolerance of NGT-B appeared to have deteriorated compared with NGT-A as determined by blood glucose, insulin, and glucosuria. There was very little effect of gender or age on deltamyo-inositol in NGT-A. deltamyo-inositol was significantly higher than that in NGT-A (0.5+/-7.1 mg/g Cr) not only in IFG (8.7+/-19.5 mg/g Cr, P0.0001), IGT (14.8+/-22.9 mg/g Cr, P0.0001) and DM (79.5+/-37.1 mg/g Cr, P0.0001), but in NGT-B (7.4+/-12.7 mg/g Cr, P0.0001). With 2 mg/g Cr as a tentative cut-off for deltamyo-inositol to detect NGT-A, sensitivity and specificity were 68% and 72%, respectively.The deltamyo-inositol can be use of a non-invasive and sensitive marker for glucose intolerance.
- Subjects :
- Adult
Male
medicine.medical_specialty
endocrine system diseases
Urinary system
Clinical Biochemistry
Biochemistry
Sensitivity and Specificity
Impaired glucose tolerance
chemistry.chemical_compound
Sex Factors
Internal medicine
Diabetes mellitus
Glucose Intolerance
medicine
Humans
Inositol
Oral glucose tolerance
Normal glucose tolerance
business.industry
Biochemistry (medical)
Age Factors
nutritional and metabolic diseases
General Medicine
Middle Aged
medicine.disease
Impaired fasting glucose
Endocrinology
chemistry
ROC Curve
Case-Control Studies
Female
business
hormones, hormone substitutes, and hormone antagonists
Biomarkers
Subjects
Details
- ISSN :
- 00098981
- Volume :
- 344
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Clinica chimica acta; international journal of clinical chemistry
- Accession number :
- edsair.doi.dedup.....6a6cf848ad91f52c13995d7da15563ec