The use of graded concentrations in studying skin sensitizers: Experimental contact sensitization in man

Human subjects were used to evaluate the skin sensitization potential of several substances used in marketed drugs and cosmetics, as well as other chemical agents. The results show that a modified Draize test is a useful, predictive patch-test procedure. Potentially strong sensitizers show a dose-response relationship when a range of concentrations of test material are used (at induction), whereas weak sensitizers may not; thus a range of concentrations of test materials may be used as a means of disclosing the potential of these compounds to produce delayed skin hypersensitivity.