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Botulinum Toxin Injections for Treatment of Drooling in Children with Cerebral Palsy: A Systematic Review and Meta-Analysis
- Source :
- Children; Volume 8; Issue 12; Pages: 1089, Children, Children, Vol 8, Iss 1089, p 1089 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Background: We aimed to review and analyse the effectiveness and safety of botulinum toxin type A (BoNT-A) injections for drooling in children with cerebral palsy. Data sources: We searched the EMBASE, MEDLINE, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library) databases from inception to January 2020. Methods: We included randomized controlled trials and observational studies which (1) involved children with cerebral palsy, (2) used BoNT-A for control of drooling, and (3) provided quantitative evaluations of drooling before and after intervention with BoNT-A. Results: Twenty-one trials met the inclusion criteria. Most studies showed that BoNT-A injections are safe and efficacious as a treatment for drooling in children with cerebral palsy. Four trials had sufficient data to pool the results for the meta-analysis. Both the drooling quotient (p = 0.002) and drooling Ffrequency and severity scale (p = 0.004) supported this conclusion. Conclusion: BoNT-A injections are a safe, reversible, effective treatment for drooling control in children with cerebral palsy that can offer effectiveness for more than 3 months with few side effects. The dosage of BoNT-A should not exceed 4 units/kg. Further studies are required to determine the optimal dosage and target glands.
- Subjects :
- Pediatrics
medicine.medical_specialty
drooling
Cochrane Library
RJ1-570
Article
Drooling
law.invention
Cerebral palsy
Randomized controlled trial
law
medicine
botulinum toxin
sialorrhea
cerebral palsy
saliva glands
business.industry
medicine.disease
Botulinum toxin
Systematic review
Meta-analysis
Pediatrics, Perinatology and Child Health
Observational study
medicine.symptom
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 22279067
- Database :
- OpenAIRE
- Journal :
- Children; Volume 8; Issue 12; Pages: 1089
- Accession number :
- edsair.doi.dedup.....6ab2a0787d8a33887c604c9b0103ce44
- Full Text :
- https://doi.org/10.3390/children8121089