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Systems biology of the metabolic network regulated by the Akt pathway
- Source :
- Biotechnology advances 30 (2012): 131–141. doi:10.1016/j.biotechadv.2011.08.004, info:cnr-pdr/source/autori:Mosca, Ettore; Barcella, Matteo; Alfieri, Roberta; Bevilacqua, Annamaria; Canti, Gianfranco; Milanesi, Luciano/titolo:Systems biology of the metabolic network regulated by the Akt pathway/doi:10.1016%2Fj.biotechadv.2011.08.004/rivista:Biotechnology advances/anno:2012/pagina_da:131/pagina_a:141/intervallo_pagine:131–141/volume:30
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Cancer has been proposed as an example of systems biology disease or network disease. Accordingly, tumor cells differ from their normal counterparts more in terms of intracellular network dynamics than single markers. Here we shall focus on a recently recognized hallmark of cancer, the deregulation of cellular energetics. The constitutive activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway has been confirmed as an essential step toward cell transformation. We will consider how the effects of Akt activation are connected with cell metabolism; more precisely, we will review existing metabolic models and discuss the current knowledge available to construct a kinetic model of the most relevant metabolic processes regulated by the PI3K/Akt pathway. The model will enable a systems biology approach to predict the metabolic targets that may inhibit cell growth under hyper activation of Akt. (C) 2011 Elsevier Inc. All rights reserved.
- Subjects :
- Systems biology
Metabolic network
Bioengineering
Biology
Models, Biological
Applied Microbiology and Biotechnology
Phosphatidylinositol 3-Kinases
Neoplasms
Animals
Humans
Protein kinase B
PI3K/AKT/mTOR pathway
Cancer
Kinetic models
Cell growth
Cell biology
Cell metabolism
Biochemistry
PI3K/Akt pathway
Signal transduction
Energy Metabolism
Proto-Oncogene Proteins c-akt
Glycolysis
Metabolic Networks and Pathways
Intracellular
Signal Transduction
Biotechnology
Subjects
Details
- ISSN :
- 07349750
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Biotechnology Advances
- Accession number :
- edsair.doi.dedup.....6ac7f0c01adb462c29f1cc942932a4ff