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The microbiological diagnosis of tuberculous meningitis: results of Haydarpasa-1 study
- Source :
- Erdem, H, Ozturk-Engin, D, Elaldi, N, Gulsun, S, Sengoz, G, Crisan, A, Johansen, I S, Inan, A, Nechifor, M, Al-Mahdawi, A, Civljak, R, Ozguler, M, Savic, B, Ceran, N, Cacopardo, B, Inal, A S, Namiduru, M, Dayan, S, Kayabas, U, Parlak, E, Khalifa, A, Kursun, E, Sipahi, O R, Yemisen, M, Akbulut, A, Bitirgen, M, Dulovic, O, Kandemir, B, Luca, C, Parlak, M, Stahl, J P, Pehlivanoglu, F, Simeon, S, Ulu-Kilic, A, Yasar, K, Yilmaz, G, Yilmaz, E, Beovic, B, Catroux, M, Lakatos, B, Sunbul, M, Oncul, O, Alabay, S, Sahin-Horasan, E, Kose, S, Shehata, G, Andre, K, Alp, A, Cosić, G, Cem Gul, H, Karakas, A, Chadapaud, S, Hansmann, Y, Harxhi, A, Kirova, V, Masse-Chabredier, I, Oncu, S, Sener, A, Tekin, R, Deveci, O, Karabay, O & Agalar, C 2014, ' The microbiological diagnosis of tuberculous meningitis : results of Haydarpasa-1 study ', Clinical Microbiology and Infection, vol. 20, no. 10, pp. O600-O608 . https://doi.org/10.1111/1469-0691.12478
- Publication Year :
- 2013
-
Abstract
- WOS: 000345825900004<br />PubMed ID: 24849547<br />We aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa-1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich-Ziehl-Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon- release assay (Quantiferon TB gold in tube) 90.2%, automated culture systems (ACS) 81.8%, Lowenstein Jensen medium (L-J) 72.7%, adenosine deaminase (ADA) 29.9% and EZNs 27.3%. CSF-ACS was superior to CSF L-J culture and CSF-PCR (p
- Subjects :
- Microbiology (medical)
Adult
Male
medicine.medical_specialty
Adolescent
QUANTIFERON-TB GOLD
diagnosis
Adenosine Deaminase
Culture
Tuberculous meningitis
03 medical and health sciences
Young Adult
0302 clinical medicine
Internal medicine
Diagnosis
medicine
Tuberculosis
Humans
Meningitis
030212 general & internal medicine
Precision Medicine
Aged
Retrospective Studies
culture
meningitis
PCR
tuberculosis
Aged, 80 and over
Bacteriological Techniques
business.industry
General Medicine
Mycobacterium tuberculosis
Middle Aged
medicine.disease
3. Good health
Surgery
Löwenstein–Jensen medium
Infectious Diseases
Early Diagnosis
Tuberculosis, Meningeal
Positive culture
Female
business
030217 neurology & neurosurgery
Interferon-gamma Release Tests
Subjects
Details
- ISSN :
- 14690691
- Volume :
- 20
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
- Accession number :
- edsair.doi.dedup.....6acb2e765e83a32bffccdf306368e6f6
- Full Text :
- https://doi.org/10.1111/1469-0691.12478