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Biological and prognostic differences between symptomatic colorectal carcinomas and those detected by screening
- Source :
- Digital.CSIC. Repositorio Institucional del CSIC, instname
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- REDISSEC-CARESS/CCR group.<br />[Introduction] Few studies have been conducted to establish the relationship between colorectal cancer screening programmes and survival adjusting by stage and, to determine whether there are differences, at a biological level, between the tumours of asymptomatic and symptomatic patients. Accordingly, the aim of this study is to evaluate clinical, biological and survival differences between symptomatic colorectal tumours and those detected by screening.<br />[Study method] A prospective cohort study was performed of patients subjected to surgical intervention during the period 2010–2012, at different hospitals in Spain. In every case, clinical, pathological, biological and survival-related variables were obtained.<br />[Results] A total of 2634 patients from the CARESS-CCR cohort were analysed; of these, 220 were diagnosed through screening. The asymptomatic patients were younger, had a higher Body Mass Index (BMI), a lower degree of perineural invasion and a less advanced T stage and nodular stage, and the tumour was frequently located on the right side of the colon. All of these differences were statistically significant. The serum tumour marker carbohydrate antigen 19.9 (CA 19.9) was found more frequently in the symptomatic patients (p<br />[Conclusions] The detection method employed influenced the survival of patients with colorectal cancer and there were no significant biological differences between the study groups.<br />This research was partially supported by grants from REDISSEC (RD12/0001/0010 and RD16/0001/0006), Instituto de Salud Carlos III (PI 09/00910, PI 13/00013, PI 18/01181) and the European Regional Development Fund.
- Subjects :
- Male
medicine.medical_specialty
Survival
Colorectal cancer
Perineural invasion
Asymptomatic
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Biomarkers, Tumor
Humans
Mass Screening
Medicine
Prospective Studies
Colorectal carcinomas
030212 general & internal medicine
Stage (cooking)
Prospective cohort study
Early Detection of Cancer
Aged
Neoplasm Staging
Biological markers
business.industry
Incidence
General Medicine
Middle Aged
medicine.disease
Immunohistochemistry
Survival Rate
Oncology
Spain
030220 oncology & carcinogenesis
Cohort
Screening
T-stage
Female
Surgery
medicine.symptom
Colorectal Neoplasms
business
Body mass index
Follow-Up Studies
Subjects
Details
- ISSN :
- 07487983
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- European Journal of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....6ad6c89543fc8cc2069f0f0cf47cfeb0