Sorry, I don't understand your search. ×
Back to Search Start Over

Reconceptualize tall-cell variant papillary thyroid microcarcinoma: From a 'sonographic histology' perspective

Reconceptualize tall-cell variant papillary thyroid microcarcinoma: From a 'sonographic histology' perspective

Authors :
Yongyue, Zhang
Fang, Mei
Xiaoxi, He
Jing, Ma
Shumin, Wang
Source :
Frontiers in Endocrinology. 13
Publication Year :
2022
Publisher :
Frontiers Media SA, 2022.

Abstract

ObjectiveThis study aimed to examine the relationship between sonographic features and histological manifestations in the tall-cell variant of papillary thyroid microcarcinoma (TCV-PTMC), thus proposing the concept of “sonographic histology” and examine its value in the clinical management of the aggressive tall-cell variant.MethodsThis study retrospectively included 104 participants who were admitted to Peking University Third Hospital from 2015 to 2022 and were histopathologically confirmed as having TCV-PTMC or classical PTMC. We mainly compared the general characteristics, sonographic characteristics, and pathological specimens between the two cohorts.ResultsHypoechoic nodules with a localized central isoechoic lesion and hypoechoic halo around nodules were most often observed in TCV-PTMC, which correlated with circumferentially distributed tumor epithelium and densely distributed tumor stroma histopathologically. Additionally, TCV-PTMC showed nodules with a more regular margin and less microcalcification than classical PTMC, which led to an underestimation of the risk of TCV-PTMC.ConclusionThe good association between the ultrasound echo pattern and tissue cell arrangement was defined as sonographic histology in this study and can be applied in the preoperative identification of TCV-PTMC. This concept may provide novel insight for the identification of special subtypes of thyroid tumors and may modify pitfalls of the Thyroid Imaging Reporting and Data System in aggressive variants of microcarcinoma.

Details

ISSN :
16642392
Volume :
13
Database :
OpenAIRE
Journal :
Frontiers in Endocrinology
Accession number :
edsair.doi.dedup.....6aee01e4fda88d3f6432291f1e31b04b
Full Text :
https://doi.org/10.3389/fendo.2022.1001477