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PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit

Authors :
Sandro Galea
Karestan C. Koenen
Allison E. Aiello
Lydia Feinstein
Graham Pawelec
Bamini Jayabalasingham
Derek E. Wildman
Caroline Cheng
Amanda M. Simanek
Monica Uddin
Jennifer Beam Dowd
Publication Year :
2016
Publisher :
The University of North Carolina at Chapel Hill University Libraries, 2016.

Abstract

Background Psychosocial stress is thought to play a key role in the acceleration of immunological aging. This study investigated the relationship between lifetime and past-year history of post-traumatic stress disorder (PTSD) and the distribution of T cell phenotypes thought to be characteristic of immunological aging. Methods Data were from 85 individuals who participated in the community-based Detroit Neighborhood Health Study. Immune markers assessed included the CD4:CD8 ratio, the ratio of late-differentiated effector (CCR7-CD45RA+CD27-CD28-) to naive (CCR7+CD45RA+CD27+CD28+) T cells, the percentage of KLRG1-expressing cells, and the percentage of CD57-expressing cells. Results In models adjusted for age, gender, race/ethnicity, education, smoking status, and medication use, we found that past-year PTSD was associated with statistically significant differences in the CD8+ T cell population, including a higher ratio of late-differentiated effector to naive T cells, a higher percentage of KLRG1+ cells, and a higher percentage of CD57+ cells. The percentage of CD57+ cells in the CD4 subset was also significantly higher and the CD4:CD8 ratio significantly lower among individuals who had experienced past-year PTSD. Lifetime PTSD was also associated with differences in several parameters of immune aging. Conclusions PTSD is associated with an aged immune phenotype and should be evaluated as a potential catalyzer of accelerated immunological aging in future studies.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....6b2a2237c62070f7ac58956703c0868a
Full Text :
https://doi.org/10.17615/xc35-1v07