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Facile Strategy for Synthesis of Silica/Polymer Hybrid Hollow Nanoparticles with Channels
- Source :
- Langmuir. 26:18503-18507
- Publication Year :
- 2010
- Publisher :
- American Chemical Society (ACS), 2010.
-
Abstract
- The silica/polymer hybrid hollow nanoparticles with channels and gatekeepers were successfully fabricated with a facile strategy by using thermoresponsive complex micelles of poly(ethylene glycol)-b-poly(N-isopropylacrylamide) (PEG-b-PNIPAM) and poly(N-isopropylacrylamide)-b-poly(4-vinylpyridine) (PNIPAM-b-P4VP) as the template. In aqueous solution, the complex micelles (PEG-b-PNIPAM/PNIPAM-b-P4VP) formed with the PNIPAM block as the core and the PEG/P4VP blocks as the mixed shell at 45 °C and pH 4.0. After shell cross-linking by 1,2-bis(2-iodoethoxyl)ethane (BIEE), tetraethylorthosilicate (TEOS) selectively well-deposited on the P4VP block and processed the sol-gel reaction. When the temperature was decreased to 4 °C, the PNIPAM block became swollen and further soluble, and the PEG-b-PNIPAM block copolymer escaped from the hybrid nanoparticles as a result of swelled PNIPAM and weak interaction between PEG and silica at pH 4.0. Therefore, the hybrid hollow silica nanoparticles with inner thermoresponsive PNIPAM as gatekeepers and channels in the silica shell were successfully obtained, which could be used for switchable controlled drug release. In the system, the complex micelles, as a template, could avoid the formation of larger aggregates during the preparation of the hybrid hollow silica nanoparticles. The thermoresponsive core (PNIPAM) could conveniently control the hollow space through the stimuli-responsive phase transition instead of calcination or chemical etching. In the meantime, the channel in the hybrid silica shell could be achieved because of the escape of PEG chains from the hybrid nanoparticles.
- Subjects :
- Hot Temperature
Materials science
Polymers
Acrylic Resins
Nanoparticle
Micelle
Polyethylene Glycols
chemistry.chemical_compound
Drug Delivery Systems
PEG ratio
Polymer chemistry
Electrochemistry
Copolymer
Nanotechnology
General Materials Science
Micelles
Spectroscopy
Sol-gel
chemistry.chemical_classification
Drug Carriers
Aqueous solution
Temperature
technology, industry, and agriculture
Surfaces and Interfaces
Polymer
Hydrogen-Ion Concentration
Silanes
Silicon Dioxide
Condensed Matter Physics
Chemistry
Solubility
chemistry
Nanoparticles
Ethylene glycol
Subjects
Details
- ISSN :
- 15205827 and 07437463
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Langmuir
- Accession number :
- edsair.doi.dedup.....6b32bff6835338b1e9909c210615cb63