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A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin
- Source :
- International Journal of Molecular Sciences, Vol 14, Iss 11, Pp 21629-21646 (2013), International Journal of Molecular Sciences, International Journal of Molecular Sciences. 2013, vol. 14, issue 11, p. 21629-21646., International Journal of Molecular Sciences; Volume 14; Issue 11; Pages: 21629-21646
- Publication Year :
- 2013
- Publisher :
- MDPI AG, 2013.
-
Abstract
- Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a consequence of chemotherapy with doxorubicin. The purpose of this study was to determine the effect of exposure to doxorubicin on the changes in major amino acids in tissue of cardiac muscle (proline, taurine, glutamic acid, arginine, aspartic acid, leucine, glycine, valine, alanine, isoleucine, threonine, lysine and serine). An in vitro interaction study was performed as a comparison of amino acid profiles in heart tissue before and after application of doxorubicin. We found that doxorubicin directly influences myocardial amino acid representation even at low concentrations. In addition, we performed an interaction study that resulted in the determination of breaking points for each of analyzed amino acids. Lysine, arginine, β-alanine, valine and serine were determined as the most sensitive amino acids. Additionally we compared amino acid profiles of myocardium before and after exposure to doxorubicin. The amount of amino acids after interaction with doxorubicin was significantly reduced (p = 0.05). This fact points at an ability of doxorubicin to induce changes in quantitative composition of amino acids in myocardium. Moreover, this confirms that the interactions between doxorubicin and amino acids may act as another factor most likely responsible for adverse effects of doxorubicin on myocardium.
- Subjects :
- Taurine
Arginine
Pharmacology
lcsh:Chemistry
chemistry.chemical_compound
0302 clinical medicine
Neoplasms
Amino Acids
lcsh:QH301-705.5
Spectroscopy
Alanine
chemistry.chemical_classification
0303 health sciences
Heart
General Medicine
Chromatography, Ion Exchange
3. Good health
Computer Science Applications
Amino acid
Biochemistry
030220 oncology & carcinogenesis
Leucine
myocardium
cardiomyopathy
interaction
amide bond
spectrophotometry
ion-exchange liquid chromatography
medicine.drug
Drug-Related Side Effects and Adverse Reactions
Antineoplastic Agents
Article
Catalysis
Inorganic Chemistry
03 medical and health sciences
Valine
medicine
Animals
Humans
Doxorubicin
Physical and Theoretical Chemistry
Molecular Biology
030304 developmental biology
Organic Chemistry
chemistry
lcsh:Biology (General)
lcsh:QD1-999
Glycine
Chickens
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 14
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....6b34edc5577edc134bf24aec748640e3