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Decreased hemodynamic response in inferior frontotemporal regions in elderly with mild cognitive impairment
- Source :
- Psychiatry Research: Neuroimaging. 274:11-18
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- The verbal fluency task (VFT) is a well-established cognitive marker for mild cognitive impairment (MCI) in the prodromal stage of Alzheimer´s dementia (AD). The behavioral VFT performance of patients allows the prediction of dementia two years later. But effective compensatory mechanism might cover or reduce the predictive value of the VFT. Therefore the aim of this study is to measure the hemodynamic response during VFT in patients with mild cognitive impairment (MCI) to establish the hemodynamic response during the VFT as a screening instrument for the prediction of dementia. One method which allows measuring the hemodynamic response during speech production without severe problems with moving artifacts like in functional magnetic resonance imaging (fMRI) is the functional near-infrared spectroscopy (fNIRS). It is optimal as a screening instrument, as it is easy to apply and without any contraindications. In this study we assessed the hemodynamic response in prefrontal and temporal regions in patients with MCI as well as matched healthy controls with fNIRS. We found a decreased hemodynamic response in the inferior frontotemporal cortex for the MCI group. Our results indicate that a frontotemporal decreased hemodynamic response could serve as a diagnostic biomarker for dementia.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Speech production
Haemodynamic response
Neuroscience (miscellaneous)
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Internal medicine
mental disorders
Humans
Medicine
Dementia
Verbal fluency test
Cognitive Dysfunction
Radiology, Nuclear Medicine and imaging
Aged
Aged, 80 and over
Cerebral Cortex
Spectroscopy, Near-Infrared
medicine.diagnostic_test
business.industry
Prodromal Stage
Hemodynamics
Cognition
medicine.disease
Magnetic Resonance Imaging
Temporal Lobe
Psychiatry and Mental health
030104 developmental biology
Cerebrovascular Circulation
Cardiology
Functional near-infrared spectroscopy
Female
business
Functional magnetic resonance imaging
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 09254927
- Volume :
- 274
- Database :
- OpenAIRE
- Journal :
- Psychiatry Research: Neuroimaging
- Accession number :
- edsair.doi.dedup.....6b5acfd6f1fceb31aeb0cee09309b31f