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Tuning the Brake While Raising the Stake:Network Dynamics during Sequential Decision-Making
- Source :
- Meder, D, Haagensen, B N, Hulme, O, Morville, T, Gelskov, S, Herz, D M, Diomsina, B, Christensen, M S, Madsen, K H & Siebner, H R 2016, ' Tuning the Brake While Raising the Stake : Network Dynamics during Sequential Decision-Making ', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 36, no. 19, pp. 5417-26 . https://doi.org/10.1523/JNEUROSCI.3191-15.2016
- Publication Year :
- 2016
-
Abstract
- When gathering valued goods, risk and reward are often coupled and escalate over time, for instance, during foraging, trading, or gambling. This escalating frame requires agents to continuously balance expectations of reward against those of risk. To address how the human brain dynamically computes these tradeoffs, we performed whole-brain fMRI while healthy young individuals engaged in a sequential gambling task. Participants were repeatedly confronted with the option to continue with throwing a die to accumulate monetary reward under escalating risk, or the alternative option to stop to bank the current balance. Within each gambling round, the accumulation of gains gradually increased reaction times for “continue” choices, indicating growing uncertainty in the decision to continue. Neural activity evoked by “continue” choices was associated with growing activity and connectivity of a cortico-subcortical “braking” network that positively scaled with the accumulated gains, including pre-supplementary motor area (pre-SMA), inferior frontal gyrus, caudate, and subthalamic nucleus (STN). The influence of the STN on continue-evoked activity in the pre-SMA was predicted by interindividual differences in risk-aversion attitudes expressed during the gambling task. Furthermore, activity in dorsal anterior cingulate cortex (ACC) reflected individual choice tendencies by showing increased activation when subjects made nondefault “continue” choices despite an increasing tendency to stop, but ACC activity did not change in proportion with subjective choice uncertainty. Together, the results implicate a key role of dorsal ACC, pre-SMA, inferior frontal gyrus, and STN in computing the trade-off between escalating reward and risk in sequential decision-making.SIGNIFICANCE STATEMENTUsing a paradigm where subjects experienced increasing potential rewards coupled with increasing risk, this study addressed two unresolved questions in the field of decision-making: First, we investigated an “inhibitory” network of regions that has so far been investigated with externally cued action inhibition. In this study, we show that the dynamics in this network under increasingly risky decisions are predictive of subjects' risk attitudes. Second, we contribute to a currently ongoing debate about the anterior cingulate cortex's role in sequential foraging decisions by showing that its activity is related to making nondefault choices rather than to choice uncertainty.
- Subjects :
- Male
Decision Making
Poison control
Inferior frontal gyrus
Gyrus Cinguli
Action selection
050105 experimental psychology
Task (project management)
03 medical and health sciences
Risk-Taking
0302 clinical medicine
Reward
Connectome
medicine
Humans
0501 psychology and cognitive sciences
Evoked Potentials
Anterior cingulate cortex
Cued speech
General Neuroscience
05 social sciences
Articles
Network dynamics
medicine.anatomical_structure
Action (philosophy)
Female
Psychology
Social psychology
psychological phenomena and processes
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Meder, D, Haagensen, B N, Hulme, O, Morville, T, Gelskov, S, Herz, D M, Diomsina, B, Christensen, M S, Madsen, K H & Siebner, H R 2016, ' Tuning the Brake While Raising the Stake : Network Dynamics during Sequential Decision-Making ', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 36, no. 19, pp. 5417-26 . https://doi.org/10.1523/JNEUROSCI.3191-15.2016
- Accession number :
- edsair.doi.dedup.....6b69a9ee28ca9d7b0f2e701403fe0bdc