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European Malignant Hyperthermia Group guidelines for investigation of malignant hyperthermia susceptibility
- Source :
- British Journal of Anaesthesia. 115:531-539
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- It is 30 yr since the British Journal of Anaesthesia published the first consensus protocol for the laboratory diagnosis of malignant hyperthermia susceptibility from the European Malignant Hyperthermia Group. This has subsequently been used in more than 10 000 individuals worldwide to inform use of anaesthetic drugs in these patients with increased risk of developing malignant hyperthermia during general anaesthesia, representing an early and successful example of stratified medicine. In 2001, our group also published a guideline for the use of DNA-based screening of malignant hyperthermia susceptibility. We now present an updated and complete guideline for the diagnostic pathway for patients potentially at increased risk of developing malignant hyperthermia. We introduce the new guideline with a narrative commentary that describes its development, the changes to previously published protocols and guidelines, and new sections, including recommendations for patient referral criteria and clinical interpretation of laboratory findings.
- Subjects :
- medicine.medical_specialty
diagnosis
malignant hyperthermia
Patient referral
Stratified medicine
CACNA1S
RYR1
excitation–contraction coupling
malignant hyperthermia susceptibility, diagnosis
skeletal muscle
medicine
Humans
Genetic Predisposition to Disease
General anaesthesia
Intensive care medicine
Referral and Consultation
business.industry
Excitation–contraction coupling
Malignant hyperthermia
malignant hyperthermia susceptibility
Guideline
medicine.disease
Europe
Anesthesiology and Pain Medicine
Increased risk
Anesthesia
business
Subjects
Details
- ISSN :
- 00070912
- Volume :
- 115
- Database :
- OpenAIRE
- Journal :
- British Journal of Anaesthesia
- Accession number :
- edsair.doi.dedup.....6b6dc75a67c70f4ca46c181b0be00944