Back to Search Start Over

Selenium Deficiency Aggravates Aflatoxin B1–Induced Immunotoxicity in Chick Spleen by Regulating 6 Selenoprotein Genes and Redox/Inflammation/Apoptotic Signaling

Authors :
Ni-Ya Zhang
Wan-Po Zhang
Xiao-Li Liu
Jiang Deng
Yue Feng
Shahid Ali Rajput
Ling Zhao
Lv-Hui Sun
Desheng Qi
Source :
The Journal of Nutrition. 149:894-901
Publication Year :
2019
Publisher :
Elsevier BV, 2019.

Abstract

BACKGROUND Selenium (Se) plays a protective role in aflatoxin B1 (AFB1)-induced splenic immunotoxicity in chicks. OBJECTIVE This study was designed to reveal the underlying mechanism of Se-mediated protection against AFB1-induced splenic injury in broilers. METHODS Four groups of 1-d-old Cobb male broilers (n = 5 cages/diet, 6 chicks/cage) were arranged in a 3-wk 2 × 2 factorial design trial whereby they were fed an Se-deficient, corn- and soy-based diet [base diet (BD), 36 μg Se/kg], BD plus 1.0 mg AFB1/kg, BD plus 0.3 mg Se/kg, or BD plus 1.0 mg AFB1/kg and 0.3 mg Se/kg (as 2-hydroxy-4-methylselenobutanoic acid). Serum and spleen were collected at week 3 to assay for cytokines, histology, redox status, selected inflammation- and apoptosis-related genes and proteins, and the selenogenome. RESULTS Dietary AFB1 induced growth retardation and spleen injury, decreasing (P

Details

ISSN :
00223166
Volume :
149
Database :
OpenAIRE
Journal :
The Journal of Nutrition
Accession number :
edsair.doi.dedup.....6b6e9662bae437bf99ca8594dcee94f5