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Soluble TNF-Like Weak Inducer of Apoptosis as a New Marker in Preeclampsia: A Pilot Clinical Study
- Source :
- Disease Markers, Disease Markers, Vol 2016 (2016)
- Publication Year :
- 2016
- Publisher :
- Hindawi Publishing Corporation, 2016.
-
Abstract
- Introduction. All findings of preeclampsia appear as the clinical consequences of diffuse endothelial dysfunction. Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) was recently introduced as a TNF related cytokine in various inflammatory and noninflammatory disorders. sTWEAK was found to be related to endothelial dysfunction in patients with chronic kidney disease. In our study we aimed to compare sTWEAK levels in women with preeclampsia to corresponding levels in a healthy pregnant control group.Materials and Methods. The study was undertaken with 33 patients with preeclampsia and 33 normal pregnant women. The concentration of sTWEAK in serum was calculated with an enzyme linked immunosorbent assay (ELISA) kit.Results. Serum creatinine, uric acid, LDH levels, and uPCR were significantly higher in the patient group compared to the control group. sTWEAK levels were significantly lower in preeclamptic patients (332 ± 144 pg/mL) than in control subjects (412 ± 166 pg/mL) (p=0.04).Discussion. Our study demonstrates that sTWEAK is decreased in patients with preeclampsia compared to healthy pregnant women. There is a need for further studies to identify the role of sTWEAK in the pathogenesis of preeclampsia and to determine whether it can be regarded as a predictor of the development of preeclampsia.
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
Adolescent
Article Subject
medicine.medical_treatment
Clinical Biochemistry
Down-Regulation
Apoptosis
Pilot Projects
030204 cardiovascular system & hematology
Preeclampsia
Pathogenesis
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Pre-Eclampsia
Pregnancy
Internal medicine
Genetics
medicine
Humans
Endothelial dysfunction
Molecular Biology
A Pilot Clinical Study.-, Disease markers, cilt.2016, ss.5930589, 2016 [YILDIRIM Z. B. , SUMNU A., BADEMLER N., KILIC E., SUMNU G., KARADAG S., GURSU M., OZEL A., BATMAZ G., ATES S., et al., -Soluble TNF-Like Weak Inducer of Apoptosis as a New Marker in Preeclampsia]
reproductive and urinary physiology
Creatinine
lcsh:R5-920
business.industry
Biochemistry (medical)
Cytokine TWEAK
General Medicine
medicine.disease
Creatine
Uric Acid
030104 developmental biology
Cytokine
Endocrinology
chemistry
Tumor Necrosis Factors
Uric acid
Tumor necrosis factor alpha
Female
business
lcsh:Medicine (General)
Biomarkers
Kidney disease
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 02780240
- Database :
- OpenAIRE
- Journal :
- Disease Markers
- Accession number :
- edsair.doi.dedup.....6b796f117cf7c9a7632c3fab36d6b0a7
- Full Text :
- https://doi.org/10.1155/2016/5930589