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Looking into dental pulp stem cells in the therapy of photoreceptors and retinal degenerative disorders
- Source :
- Journal of photochemistry and photobiology. B, Biology. 203
- Publication Year :
- 2019
-
Abstract
- Blindness and vision impairment are caused by irremediable retinal degeneration in affected individuals worldwide. Cell therapy for a retinal replacement can potentially rescue their vision, specifically for those who lost the light sensing photoreceptors in the eye. As such, well-characterized retinal cells are required for the replacement purposes. Stem cell-based therapy in photoreceptor and retinal pigment epithelium transplantation is well received, however, the drawbacks of retinal transplantation is the limited clinical protocols development, insufficient number of transplanted cells for recovery, the selection of potential stem cell sources that can be differentiated into the target cells, and the ability of cells to migrate to the host tissue. Dental pulp stem cells (DPSC) belong to a subset of mesenchymal stem cells, and are recently being studied due to its high capability of differentiating into cells of the neuronal lineage. In this review, we look into the potential uses of DPSC in treating retinal degeneration, and also the current data supporting its application.
- Subjects :
- Retinal degeneration
medicine.medical_treatment
Biophysics
Retina
chemistry.chemical_compound
Dental pulp stem cells
medicine
Humans
Radiology, Nuclear Medicine and imaging
Photoreceptor Cells
Dental Pulp
Radiation
Retinal pigment epithelium
Radiological and Ultrasound Technology
business.industry
Stem Cells
Retinal Degeneration
Retinal
Stem-cell therapy
medicine.disease
Transplantation
medicine.anatomical_structure
chemistry
Stem cell
business
Neuroscience
Stem Cell Transplantation
Subjects
Details
- ISSN :
- 18732682
- Volume :
- 203
- Database :
- OpenAIRE
- Journal :
- Journal of photochemistry and photobiology. B, Biology
- Accession number :
- edsair.doi.dedup.....6b95976072285c0ea70f24006aa3017a