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E1A signaling to p53 involves the p19ARFtumor suppressor
E1A signaling to p53 involves the p19ARFtumor suppressor
- Source :
- Genes & Development. 12:2434-2442
- Publication Year :
- 1998
- Publisher :
- Cold Spring Harbor Laboratory, 1998.
-
Abstract
- The adenovirus E1A oncogene activates p53 through a signaling pathway involving the retinoblastoma protein and the tumor suppressor p19ARF. The ability of E1A to induce p53 and its transcriptional targets is severely compromised in ARF-null cells, which remain resistant to apoptosis following serum depletion or adriamycin treatment. Reintroduction of p19ARF restores p53 accumulation and resensitizes ARF-null cells to apoptotic signals. Therefore, p19ARF functions as part of a p53-dependent failsafe mechanism to counter uncontrolled proliferation. Synergistic effects between the p19ARF and DNA damage pathways in inducing p53 may contribute to E1A’s ability to enhance radio- and chemosensitivity.
- Subjects :
- Genes, Viral
DNA damage
Apoptosis
Biology
law.invention
Mice
law
Tumor Suppressor Protein p14ARF
Genetics
Animals
Genes, Tumor Suppressor
Cells, Cultured
Mice, Knockout
Regulation of gene expression
Oncogene
Retinoblastoma protein
Proteins
Genes, p53
Tumor Suppressor ARF
Gene Expression Regulation
biology.protein
Cancer research
Suppressor
Adenovirus E1A Proteins
Signal transduction
Cell Division
DNA Damage
Signal Transduction
Research Paper
Developmental Biology
Subjects
Details
- ISSN :
- 15495477 and 08909369
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Genes & Development
- Accession number :
- edsair.doi.dedup.....6bb62d1272ee7783fbe9c5da16fb0206
- Full Text :
- https://doi.org/10.1101/gad.12.15.2434