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Porphyrin as Diagnostic and Therapeutic Agent
- Source :
- Molecules, Vol 24, Iss 14, p 2669 (2019), Molecules
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- The synthesis and application of porphyrins has seen a huge shift towards research in porphyrin bio-molecular based systems in the past decade. The preferential localization of porphyrins in tumors, as well as their ability to generate reactive singlet oxygen and low dark toxicities has resulted in their use in therapeutic applications such as photodynamic therapy. However, their inherent lack of bio-distribution due to water insolubility has shifted research into porphyrin-nanomaterial conjugated systems to address this challenge. This has broadened their bio-applications, viz. bio-sensors, fluorescence tracking, in vivo magnetic resonance imaging (MRI), and positron emission tomography (PET)/CT imaging to photo-immuno-therapy just to highlight a few. This paper reviews the unique theranostic role of porphyrins in disease diagnosis and therapy. The review highlights porphyrin conjugated systems and their applications. The review ends by bringing current challenges and future perspectives of porphyrin based conjugated systems and their respective applications into light.
- Subjects :
- Porphyrins
PTT
medicine.medical_treatment
theranostic
Pharmaceutical Science
Photodynamic therapy
Nanotechnology
Review
Conjugated system
Theranostic Nanomedicine
Analytical Chemistry
lcsh:QD241-441
Mice
chemistry.chemical_compound
conjugate
PDT
lcsh:Organic chemistry
Neoplasms
Drug Discovery
medicine
polycyclic compounds
Animals
Humans
Physical and Theoretical Chemistry
Photosensitizing Agents
Singlet Oxygen
Chemistry
Singlet oxygen
Organic Chemistry
Water
dual modality
Magnetic Resonance Imaging
Porphyrin
Photochemotherapy
Chemistry (miscellaneous)
Positron-Emission Tomography
Molecular Medicine
Dual modality
Ct imaging
Glycoconjugates
porphyrin
MRI
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 24
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....6bc692d50b266a5ea936766c257d47f3