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Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation
Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation
- Source :
- Cell Death Discovery, Cell Death Discovery, Springer Nature, 2019, 5 (1), pp.150. ⟨10.1038/s41420-019-0234-y⟩, Cell Death Discovery, 2019, 5, ⟨10.1038/s41420-019-0234-y⟩, Cell Death Discovery, Vol 5, Iss 1, Pp 1-15 (2019), Cell Death Discovery, Springer Nature, 2019, 5, ⟨10.1038/s41420-019-0234-y⟩
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- Abstract Iron overload, notably caused by hereditary hemochromatosis, is an excess storage of iron in various organs that causes tissue damage and may promote tumorigenesis. To manage that disorder, free iron depletion can be induced by iron chelators like deferoxamine that are of increasing interest also in the cancer field since iron stock could be a potent target for managing tumorigenesis. Curcumin, a well-known active substance extracted from the turmeric rhizome, destabilizes endoplasmic reticulum, and secondarily lysosomes, thereby increasing mitophagy/autophagy and subsequent apoptosis. Recent findings show that cells treated with curcumin also exhibit a decrease in ferritin, which is consistent with its chemical structure and iron chelating activity. Here we investigated how curcumin influences the intracellular effects of iron overload via Fe-nitriloacetic acid or ferric ammonium citrate loading in Huh-7 cells and explored the consequences in terms of antioxidant activity, autophagy, and apoptotic signal transduction. In experiments with T51B and RL-34 epithelial cells, we have found evidence that curcumin-iron complexation abolishes both curcumin-induced autophagy and apoptosis, together with the tumorigenic action of iron overload.
- Subjects :
- 0301 basic medicine
Cell death
Cancer Research
Programmed cell death
Cell biology
Immunology
[SDV.CAN]Life Sciences [q-bio]/Cancer
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
[SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
lcsh:RC254-282
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Mitophagy
medicine
[SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
Neoplastic transformation
lcsh:QH573-671
1234567890()
biology
lcsh:Cytology
Autophagy
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
3. Good health
Deferoxamine
Ferritin
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Hereditary hemochromatosis
[SDV.TOX]Life Sciences [q-bio]/Toxicology
Curcumin
biology.protein
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20587716
- Database :
- OpenAIRE
- Journal :
- Cell Death Discovery, Cell Death Discovery, Springer Nature, 2019, 5 (1), pp.150. ⟨10.1038/s41420-019-0234-y⟩, Cell Death Discovery, 2019, 5, ⟨10.1038/s41420-019-0234-y⟩, Cell Death Discovery, Vol 5, Iss 1, Pp 1-15 (2019), Cell Death Discovery, Springer Nature, 2019, 5, ⟨10.1038/s41420-019-0234-y⟩
- Accession number :
- edsair.doi.dedup.....6bd033542b500867bbe45a1a7e1ade8b
- Full Text :
- https://doi.org/10.1038/s41420-019-0234-y⟩