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Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation

Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation

Authors :
Patrice X. Petit
Gaël Nicolas
Franck Sureau
Aoula Moustapha
Ana Šarić
Nathan E. Rainey
Saints-Pères Paris Institute for Neurosciences (SPINN - UMR 8003)
Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)
Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148))
Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Division of Molecular Medicine [Zagreb, Croatia]
Rudjer Boskovic Institute [Zagreb]
Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149))
Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Laboratoire Jean PERRIN
Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)
Sureau, Franck
Saints-Pères Paris Institute for Neurosciences (SPPIN - UMR 8003)
Génétique du cancer et des maladies neuropsychiatriques (GMFC)
Université de Rouen Normandie (UNIROUEN)
Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Sorbonne Université (SU)
Laboratoire Jean Perrin (LJP)
Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)
Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Source :
Cell Death Discovery, Cell Death Discovery, Springer Nature, 2019, 5 (1), pp.150. ⟨10.1038/s41420-019-0234-y⟩, Cell Death Discovery, 2019, 5, ⟨10.1038/s41420-019-0234-y⟩, Cell Death Discovery, Vol 5, Iss 1, Pp 1-15 (2019), Cell Death Discovery, Springer Nature, 2019, 5, ⟨10.1038/s41420-019-0234-y⟩
Publication Year :
2019
Publisher :
HAL CCSD, 2019.

Abstract

Abstract Iron overload, notably caused by hereditary hemochromatosis, is an excess storage of iron in various organs that causes tissue damage and may promote tumorigenesis. To manage that disorder, free iron depletion can be induced by iron chelators like deferoxamine that are of increasing interest also in the cancer field since iron stock could be a potent target for managing tumorigenesis. Curcumin, a well-known active substance extracted from the turmeric rhizome, destabilizes endoplasmic reticulum, and secondarily lysosomes, thereby increasing mitophagy/autophagy and subsequent apoptosis. Recent findings show that cells treated with curcumin also exhibit a decrease in ferritin, which is consistent with its chemical structure and iron chelating activity. Here we investigated how curcumin influences the intracellular effects of iron overload via Fe-nitriloacetic acid or ferric ammonium citrate loading in Huh-7 cells and explored the consequences in terms of antioxidant activity, autophagy, and apoptotic signal transduction. In experiments with T51B and RL-34 epithelial cells, we have found evidence that curcumin-iron complexation abolishes both curcumin-induced autophagy and apoptosis, together with the tumorigenic action of iron overload.

Details

Language :
English
ISSN :
20587716
Database :
OpenAIRE
Journal :
Cell Death Discovery, Cell Death Discovery, Springer Nature, 2019, 5 (1), pp.150. ⟨10.1038/s41420-019-0234-y⟩, Cell Death Discovery, 2019, 5, ⟨10.1038/s41420-019-0234-y⟩, Cell Death Discovery, Vol 5, Iss 1, Pp 1-15 (2019), Cell Death Discovery, Springer Nature, 2019, 5, ⟨10.1038/s41420-019-0234-y⟩
Accession number :
edsair.doi.dedup.....6bd033542b500867bbe45a1a7e1ade8b
Full Text :
https://doi.org/10.1038/s41420-019-0234-y⟩