Asymmetric Total Synthesis and Revision of the Absolute Configuration of 4-Keto-Clonostachydiol

Authors :: Tuo Jiang
Junjie Han
Xing Huo
Yingpeng Su
Xinfu Pan
Xuegong She
Yanfen Xu
Source :: The Journal of Organic Chemistry. 74:3930-3932
Publication Year :: 2009
Publisher :: American Chemical Society (ACS), 2009.
Abstract: The first total synthesis of the 14-membered natural macrocyclic bislactone 4-keto-clonostachydiol, along with its enantiomer, has been accomplished in 13 steps with overall yields of 8.4% and 8.0%, respectively. The absolute configuration of 4-keto-clonostachydiol 1 has been revised as (5S,10S,13S).

Subjects :: chemistry.chemical_classification
Ketone
Stereochemistry
Clonostachydiol
Organic Chemistry
Enantioselective synthesis
Absolute configuration
Total synthesis
Stereoisomerism
Substrate Specificity
Lactones
chemistry
4-keto-clonostachydiol
Epoxy Compounds
Enantiomer
Lactone

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