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A water-soluble two-photon ratiometric triarylboron probe with nucleolar targeting by preferential RNA binding
- Source :
- Chemical communications (Cambridge, England). 53(83)
- Publication Year :
- 2017
-
Abstract
- By functionalizing triarylboron with cyclen, we developed a two-photon fluorescence probe, TAB-2, which can selectively bind RNA with a ratiometric readout. We tested TAB-2 in NIH/3T3 fibroblast cells, and demonstrated its capability in visualizing nucleoli and analyzing microenvironment polarity by two-photon and fluorescence-lifetime imaging microscopy.
- Subjects :
- Boron Compounds
Nucleolus
010402 general chemistry
01 natural sciences
Catalysis
chemistry.chemical_compound
Mice
Two-photon excitation microscopy
Cyclen
Microscopy
Materials Chemistry
medicine
Molecule
Animals
Fibroblast
Fluorescent Dyes
Molecular Structure
010405 organic chemistry
Metals and Alloys
RNA
Water
Hydrogen Bonding
General Chemistry
Fibroblasts
Fluorescence
Molecular biology
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
medicine.anatomical_structure
chemistry
Microscopy, Fluorescence
Ceramics and Composites
Biophysics
NIH 3T3 Cells
Cell Nucleolus
Subjects
Details
- ISSN :
- 1364548X
- Volume :
- 53
- Issue :
- 83
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....6be119242e9d68a9dc5a6e399ef81af4