Back to Search
Start Over
Lovastatin dose-dependently potentiates the pro-inflammatory activity of lipopolysaccharide both in vitro and in vivo
- Source :
- Journal of Cardiovascular Translational Research
- Publication Year :
- 2013
-
Abstract
- Since contradictory findings have been reported on potential effects of statins in modulating the inflammatory response, we have analysed the biological activity of lovastatin both in vitro using the Raw 264.7 murine macrophagic cell line and in vivo using BALB/c mice. When added to Raw 264.7 cells in combination with lipopolysaccharide, lovastatin significantly potentiated the release of interleukin-1β, interleukin-6 and interleukin-12 with respect to lipopolysaccharide alone and showed an additive effect on the release of nitric oxide. Similarly, when lovastatin was intraperitoneally administrated to BALB/c mice, it did not induce any pro-inflammatory effect when used alone, but it significantly potentiated the pro-inflammatory activity of lipopolysaccharide, in terms of number of intraperitoneal cells and serum levels of serum amyloid A, interleukin-1β, interleukin-6 and interleukin-12. A potential clinical implication of our study is that lovastatin might exert a pro-inflammatory activity in subjects affected by inflammatory processes, with clinically evident or subclinical infections.
- Subjects :
- Lipopolysaccharides
Male
Time Factors
Lipopolysaccharide
Macrophage
Animals
Cell Line
Cholesterol
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Synergism
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Inflammation
Inflammation Mediators
Interleukin-12
Interleukin-1beta
Interleukin-6
Macrophages
Mice
Mice, Inbred BALB C
Nitric Oxide
Serum Amyloid A Protein
Pharmaceutical Science
Pharmacology
chemistry.chemical_compound
Genetics(clinical)
Inflammation Mediator
Inbred BALB C
Genetics (clinical)
Biological activity
Molecular Medicine
Cytokines
lipids (amino acids, peptides, and proteins)
Lovastatin
Drug
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.drug
Statin
Time Factor
medicine.drug_class
Biology
Article
Nitric oxide
Dose-Response Relationship
In vivo
Genetics
medicine
Serum amyloid A
Animal
chemistry
Disease Models
Hydroxymethylglutaryl-CoA Reductase Inhibitor
Subjects
Details
- ISSN :
- 19375395
- Volume :
- 6
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of cardiovascular translational research
- Accession number :
- edsair.doi.dedup.....6be1835345d4c557139ba0995d8c0fac