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The predictors of sustained virological response with sofosbuvir and ribavirin in patients with chronic hepatitis C genotype 2

Authors :
Dong Uk Kim
Gwang Ha Kim
Sung Ik Pyeon
Mong Cho
Sang Gyu Park
Geun Am Song
Hyun Young Woo
Jeong Heo
Young Joo Park
Sung Yong Han
Hyung Hoi Kim
Source :
The Korean Journal of Internal Medicine, Vol 36, Iss 3, Pp 544-556 (2021), The Korean Journal of Internal Medicine
Publication Year :
2021
Publisher :
Korean Association of Internal Medicine, 2021.

Abstract

Background/Aims: Real-world, clinical practice data are lacking about sofosbuvir/ ribavirin (SOF/RBV) treatment of Korean patients with hepatitis C virus genotype 2 (HCV GT2) infection. This study investigated the efficacy and safety of SOF/RBV in Korean patients with HCV GT2 infection and clinical factors predicting sus tained virological response 12 weeks (SVR12) after the end of SOF/RBV treatment. Methods: A total of 181 patients with HCV GT2 with/without cirrhosis were treat ed with SOF/RBV for 16/12 weeks. Rapid virological response (RVR) was defined as non-detectable HCV RNA at 4 weeks. Results: The RVR rate was 80.7% (146/181), the end of treatment response rate was 97.8% (177/181) and the SVR12 rate was 92.8% (168/181). Of eight patients with relapse, four did not achieve RVR. Three patients had a history of hepatocellular carcinoma (HCC). Multivariable analysis showed that RVR (p = 0.015) and no pre vious history of HCC (p = 0.007) were associated with SVR12. Factors significantly contributing to RVR included cirrhosis, creatinine concentration, and pre-treat ment HCV RNA level. SVR12 rate was significantly higher in RVR (+) than RVR (-) patients (95.2% vs. 82.9%, p = 0.011) and also significantly higher in patients with out than with a history of HCC (94.1% vs. 72.7%, p = 0.008). During treatment, 80/181 patients (44.2%) experienced mild to moderate adverse events, with 32 (17.7%) requiring RBV dose reductions due to anemia. Conclusions: SOF/RBV treatment was effective and tolerable in HCV GT2 pa tients. RVR and no previous history of HCC were positive predictors of SVR12.

Details

ISSN :
20056648 and 12263303
Volume :
36
Database :
OpenAIRE
Journal :
The Korean Journal of Internal Medicine
Accession number :
edsair.doi.dedup.....6bea297926f75edc8592a911ceb41959