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Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs
- Source :
- Cell Adhesion & Migration, Vol 13, Iss 1, Pp 284-291 (2019), Cell Adhesion & Migration
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- Snail2 is a repressor of E-cadherin during carcinogenesis; however, the specific mechanisms involved in this process remain largely unknown. Here, we determined that Snail2 was highly increased during TGF-β-induced EMT process in lung cells. H3K9 methylation was up-regulated and H3K4/H3K56 acetylation were down-regulated at the E-cadherin promoter. Snail2 interacted with G9a and HDACs to exert suppression of E-cadherin transcription. Overexpression of Snail2 enhanced the migration and invasion ability, whereas G9a and HDACs inhibition significantly reversed this effect. Our study demonstrated the importance of G9a- and HDACs-mediated regulation during Snail2-induced E-cadherin repression and metastasis during LC progression.
- Subjects :
- 0301 basic medicine
Lung Neoplasms
snail2
Short Communication
epithelial-mesenchymal transition
Repressor
medicine.disease_cause
Methylation
Histone Deacetylases
Metastasis
Histones
Transforming Growth Factor beta1
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Antigens, CD
Transcription (biology)
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Histocompatibility Antigens
medicine
Humans
metastasis
Epithelial–mesenchymal transition
lcsh:QH573-671
Promoter Regions, Genetic
Psychological repression
g9a
lcsh:Cytology
Cadherin
Chemistry
Acetylation
Histone-Lysine N-Methyltransferase
Cell Biology
Cadherins
medicine.disease
Gene Expression Regulation, Neoplastic
Histone Deacetylase Inhibitors
030104 developmental biology
A549 Cells
030220 oncology & carcinogenesis
Cancer research
Snail Family Transcription Factors
hdacs
lung carcinoma
Carcinogenesis
Subjects
Details
- ISSN :
- 19336926 and 19336918
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Cell Adhesion & Migration
- Accession number :
- edsair.doi.dedup.....6bead364fc48fb7bd80a3d6c63f70e11