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Fabrication of Complex Micelles with Tunable Shell for Application in Controlled Drug Release
- Source :
- Macromolecular Bioscience. 9:1185-1193
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- At room temperature, diblock copolymers of PLA-b-PNIPAM and PEG-b-PLA self-assembled into complex micelles with a PLA core and a mixed PEG/PNIPAM shell. By increasing the temperature, these complex micelles could be converted into a core-shell-corona structure composed of a PLA core, a collapsed PNIPAM shell and a soluble PEG corona, and the PEG chains stretched from the inner core to outside, leading to the formation of PEG channels. The PEG channels could be used for the exchange of substance between the core and the external environment. Compared with core-shell micelles, complex micelles with a core-shell-corona structure could avoid the burst diffusion in the release of ibuprofen and inhibit the degradation of PLA by lipase to a certain extent.
- Subjects :
- Drug Carriers
Magnetic Resonance Spectroscopy
Materials science
Hydrodynamic radius
Aqueous solution
Polymers and Plastics
Polymers
Diffusion
technology, industry, and agriculture
Inner core
Bioengineering
macromolecular substances
respiratory system
equipment and supplies
Micelle
Biomaterials
Microscopy, Electron, Transmission
stomatognathic system
PEG ratio
Polymer chemistry
Materials Chemistry
Copolymer
Drug carrier
Micelles
Biotechnology
Subjects
Details
- ISSN :
- 16165195 and 16165187
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Macromolecular Bioscience
- Accession number :
- edsair.doi.dedup.....6bee7f81b58b93f7970e88299bc1ab79