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Antiviral and Cytotoxic Isocoumarin Derivatives from an Endophytic Fungus Aspergillus oryzae
- Source :
- Planta medica. 82(5)
- Publication Year :
- 2016
-
Abstract
- Oryzaeins A-D (1-4), four new isocoumarin derivatives, along with five known ones (5-9) were isolated from solid cultures of an endophytic fungus Aspergillus oryzae. Their structures were elucidated by detailed spectroscopic analysis and by comparison with reported data of related derivatives. Among them, compounds 1 and 2 represent the first examples of isocoumarins possessing an unusual 2-oxopropyl group and a rare 3-hydroxypropyl group. Compounds 1 and 2 displayed moderate anti-tobacco mosaic virus activities with inhibition rates of 28.4% and 30.6%, respectively, at the concentration of 20 µM. The new compounds showed moderate inhibitory activities against several human tumor cell lines with IC50 values in the range of 2.8-8.8 µM. Supporting information available online at http://www.thieme-connect.de/products.
- Subjects :
- China
Stereochemistry
Aspergillus oryzae
Isocoumarins
Pharmaceutical Science
Antineoplastic Agents
01 natural sciences
Antiviral Agents
Analytical Chemistry
chemistry.chemical_compound
Cell Line, Tumor
Drug Discovery
Cytotoxic T cell
Humans
Cytotoxicity
Pharmacology
Trichocomaceae
biology
Mosaic virus
Molecular Structure
010405 organic chemistry
business.industry
Organic Chemistry
biology.organism_classification
0104 chemical sciences
Biotechnology
Anti-Bacterial Agents
Isocoumarin
Tobacco Mosaic Virus
010404 medicinal & biomolecular chemistry
Complementary and alternative medicine
chemistry
Cell culture
Molecular Medicine
Drug Screening Assays, Antitumor
business
Subjects
Details
- ISSN :
- 14390221
- Volume :
- 82
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Planta medica
- Accession number :
- edsair.doi.dedup.....6bf44b92fdefe6dac6fb1dc8323a066c