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A comparative study on clinical characterizations between acute myelitis onset of neuromyelitis optica spectrum disease and idiopathic transverse myelitis
- Source :
- Neurological Research. 42:612-617
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- Both of neuromyelitis optica spectrum disease (NMOSDs) and idiopathic transverse myelitis (ITM) could present as acute transverse myelitis. However, long-term immunological treatment and prognosis are different for high recurrence of NMOSDs. In this study, we summarized clinical differences between acute attack myelitis of NMOSDs and ITM, we further screened serum auto-antibodies to help understand the two distinct clinical entities.This is a retrospective study on 48 NMOSD patients and 49 ITM patients in neurological department of Nanjing Drum Tower Hospital from 2013 to 2019. Clinical, CSF and MRI profiles on the acute episode were also compared between NMOSD patients and ITM patients. Serum AQP4 and auto-antibodies were tested. Clinical parameters were further compared between NMOSD patients with and without auto-antibodies.Compared with ITM patients, NMOSD patients manifested with longer vertebral segments (5.42 ± 3.17 segmentsNMOSD patients manifested with longer vertebral segments, higher female/male ratio, IgG index, anti-ANAs, anti-Ro-52 and anti-SSA seroprevalence than ITM patients. These features may help clinicians better distinguish NMOSD from ITM and provide long-term immunotherapy reasonably.
- Subjects :
- Adult
Male
0301 basic medicine
Pathology
medicine.medical_specialty
Myelitis
Disease
Myelitis, Transverse
Autoantigens
Idiopathic transverse myelitis
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Aged
Autoantibodies
Retrospective Studies
Neuromyelitis optica
business.industry
Neuromyelitis Optica
General Medicine
Middle Aged
medicine.disease
eye diseases
030104 developmental biology
Acute Transverse Myelitis
Neurology
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 17431328 and 01616412
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Neurological Research
- Accession number :
- edsair.doi.dedup.....6bf768b8975b1382404f76f7b68e4c7a