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A differential sex-specific pattern of IgG2 and IgG4 subclasses of anti-drug antibodies (ADAs) induced by glatiramer acetate in relapsing-remitting multiple sclerosis patients
- Source :
- Multiple sclerosis and related disorders. 34
- Publication Year :
- 2019
-
Abstract
- Background Glatiramer acetate (GA) is a drug for Multiple Sclerosis (MS) treatment. However, its administration induces anti-drug antibodies (ADA). This research evaluated the sex differences in humoral response against GA in RR-MS patients Methods We analyzed 69 RR-MS patients, 43 treated with GA and 26 treated with IFN-β. In all cases, the serum concentration of IgG antibodies was determined by UPLC, whereas the levels of IgG subclasses (1–4) of anti-GA antibodies and the concentration of IL-6 were detected by Multiplex and IL-10, and IFN-γ were detected by ELISA. Results The total concentration of IgG antibodies in patients did not differ between treatments, whereas the IgG levels of ADA were higher in male and female patients treated with GA (P ≤ 0.0001). The subclasses of IgG anti-GA antibodies were as follows: IgG4>>IgG3>IgG1>IgG2. Statistical analysis showed differences in the IgG2 (P ≤ 0.01) and IgG4 (P ≤ 0.0001) subclasses by sex in RR-MS patients. Levels of IgG1 subclass in male patients correlated positively with the circulatory levels of IL-6 (rs = 0.587, P ≤ 0.04) and IFN-γ (rs = 0.721, P ≤ 0.001), while IgG2 subclass levels in female patients correlated with serum levels of IFN-γ (rs = 0.628, P ≤ 0.0006). Statistical analysis did not detect correlations between the levels of IgG (1–4) subclasses of anti-GA antibodies and the evaluated clinical parameters. Conclusion This study showed differences in the levels of IgG2 and IgG4 subclasses of ADA between male and female RR-MS patients. Further studies are necessary to take advantage of the clinical potential of this finding.
- Subjects :
- Drug
Adult
Male
media_common.quotation_subject
Subclass
03 medical and health sciences
Interferon-gamma
0302 clinical medicine
Multiple Sclerosis, Relapsing-Remitting
medicine
Humans
In patient
030212 general & internal medicine
Glatiramer acetate
media_common
Sex Characteristics
biology
business.industry
Multiple sclerosis
General Medicine
Glatiramer Acetate
medicine.disease
Sex specific
Neurology
Relapsing remitting
Immunoglobulin G
Immunology
biology.protein
Female
Neurology (clinical)
Antibody
business
030217 neurology & neurosurgery
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 22110356
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Multiple sclerosis and related disorders
- Accession number :
- edsair.doi.dedup.....6c021191eed4411877e92d8b975c3f40