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Plasma protein-based signature predicts distant metastasis and induction chemotherapy benefit in Nasopharyngeal Carcinoma
Plasma protein-based signature predicts distant metastasis and induction chemotherapy benefit in Nasopharyngeal Carcinoma
- Source :
- Theranostics
- Publication Year :
- 2020
- Publisher :
- Ivyspring International Publisher, 2020.
-
Abstract
- Rationale: Currently, for locoregionally advanced nasopharyngeal carcinoma (LA-NPC), there is no effective blood-based method to predict distant metastasis. We aimed to detect plasma protein profiles to identify biomarkers that could distinguish patients with NPC who are at high risk of posttreatment distant metastasis. Methods: A high-throughput antibody array was initially applied to detect 1000 proteins in pretreatment plasma from 16 matched LA-NPC patients with or without distant metastasis after radical treatment. Differentially expressed proteins were further examined using a low-throughput array to construct a plasma protein-based signature for distant metastasis (PSDM) in a cohort of 226 patients. Results: Fifty circulating proteins were differentially expressed between metastatic and non-metastatic patients and 18 were proven to be strongly correlated with distant metastasis-free survival (DMFS) in NPC. A PSDM signature consisting of five proteins (SLAMF5, ESM-1, MMP-8, INSR, and Serpin A5) was established to assign patients with NPC into a high-risk group and a low-risk group. Patients in the high-risk group had shorter DMFS (P < 0.001), disease-free survival (DFS) (P < 0.001) and overall survival (OS) (P < 0.001). Moreover, the PSDM performed better than N stage and Epstein-Barr virus (EBV) DNA load at effectively identifying patients with NPC at high risk of metastasis. For patients in the high-risk group, induction chemotherapy significantly improved DMFS, DFS, and OS. Conclusions: The PSDM could be a useful liquid biopsy tool to effectively predict distant metastasis and the benefit of induction chemotherapy in patients with LA-NPC.
- Subjects :
- Male
0301 basic medicine
Oncology
Herpesvirus 4, Human
induction chemotherapy benefit
medicine.medical_specialty
Antibody microarray
Medicine (miscellaneous)
Disease-Free Survival
Metastasis
Cohort Studies
Plasma
03 medical and health sciences
0302 clinical medicine
distant metastasis
Risk Factors
Internal medicine
Biomarkers, Tumor
medicine
Humans
Neoplasm Metastasis
Liquid biopsy
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Nasopharyngeal Carcinoma
liquid biopsy
business.industry
Distant metastasis
Induction chemotherapy
Nasopharyngeal Neoplasms
Blood Proteins
Induction Chemotherapy
Middle Aged
Prognosis
medicine.disease
Blood proteins
030104 developmental biology
Nasopharyngeal carcinoma
030220 oncology & carcinogenesis
DNA, Viral
Cohort
Female
business
Protein-based signature
Research Paper
Subjects
Details
- ISSN :
- 18387640
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Theranostics
- Accession number :
- edsair.doi.dedup.....6c0e697834922389c4486331b768ae00
- Full Text :
- https://doi.org/10.7150/thno.47882