Back to Search Start Over

Plasma protein-based signature predicts distant metastasis and induction chemotherapy benefit in Nasopharyngeal Carcinoma

Plasma protein-based signature predicts distant metastasis and induction chemotherapy benefit in Nasopharyngeal Carcinoma

Authors :
Ying Guo
Qingmei He
Jun-Yan Li
Yan Ping Mao
Qian Li
Yin Zhao
Ya-Qin Wang
Shi-Wei He
Pan-Pan Zhang
Na Liu
Xiao-Hong Hong
Ying-Qin Li
Lei Chen
Ling-Long Tang
Ye-Lin Liang
Xiao-Jing Yang
Yuan Lei
Jun Ma
Source :
Theranostics
Publication Year :
2020
Publisher :
Ivyspring International Publisher, 2020.

Abstract

Rationale: Currently, for locoregionally advanced nasopharyngeal carcinoma (LA-NPC), there is no effective blood-based method to predict distant metastasis. We aimed to detect plasma protein profiles to identify biomarkers that could distinguish patients with NPC who are at high risk of posttreatment distant metastasis. Methods: A high-throughput antibody array was initially applied to detect 1000 proteins in pretreatment plasma from 16 matched LA-NPC patients with or without distant metastasis after radical treatment. Differentially expressed proteins were further examined using a low-throughput array to construct a plasma protein-based signature for distant metastasis (PSDM) in a cohort of 226 patients. Results: Fifty circulating proteins were differentially expressed between metastatic and non-metastatic patients and 18 were proven to be strongly correlated with distant metastasis-free survival (DMFS) in NPC. A PSDM signature consisting of five proteins (SLAMF5, ESM-1, MMP-8, INSR, and Serpin A5) was established to assign patients with NPC into a high-risk group and a low-risk group. Patients in the high-risk group had shorter DMFS (P < 0.001), disease-free survival (DFS) (P < 0.001) and overall survival (OS) (P < 0.001). Moreover, the PSDM performed better than N stage and Epstein-Barr virus (EBV) DNA load at effectively identifying patients with NPC at high risk of metastasis. For patients in the high-risk group, induction chemotherapy significantly improved DMFS, DFS, and OS. Conclusions: The PSDM could be a useful liquid biopsy tool to effectively predict distant metastasis and the benefit of induction chemotherapy in patients with LA-NPC.

Details

ISSN :
18387640
Volume :
10
Database :
OpenAIRE
Journal :
Theranostics
Accession number :
edsair.doi.dedup.....6c0e697834922389c4486331b768ae00
Full Text :
https://doi.org/10.7150/thno.47882