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Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort
- Source :
- The Journals of Gerontology: Series A, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- BackgroundHospitalized COVID-19 patients tend to be older and frequently have hypertension, diabetes, or coronary heart disease, but whether these comorbidities are true risk factors (ie, more common than in the general older population) is unclear. We estimated associations between preexisting diagnoses and hospitalized COVID-19 alone or with mortality, in a large community cohort.MethodsUK Biobank (England) participants with baseline assessment 2006–2010, followed in hospital discharge records to 2017 and death records to 2020. Demographic and preexisting common diagnoses association tested with hospitalized laboratory-confirmed COVID-19 (March 16 to April 26, 2020), alone or with mortality, in logistic models.ResultsOf 269 070 participants aged older than 65, 507 (0.2%) became COVID-19 hospital inpatients, of which 141 (27.8%) died. Common comorbidities in hospitalized inpatients were hypertension (59.6%), history of fall or fragility fractures (29.4%), coronary heart disease (21.5%), type 2 diabetes (type 2, 19. 9%), and asthma (17.6%). However, in models adjusted for comorbidities, age group, sex, ethnicity, and education, preexisting diagnoses of dementia, type 2 diabetes, chronic obstructive pulmonary disease, pneumonia, depression, atrial fibrillation, and hypertension emerged as independent risk factors for COVID-19 hospitalization, the first 5 remaining statistically significant for related mortality. Chronic kidney disease and asthma were risk factors for COVID-19 hospitalization in women but not men.ConclusionsThere are specific high-risk preexisting comorbidities for COVID-19 hospitalization and related deaths in community-based older men and women. These results do not support simple age-based targeting of the older population to prevent severe COVID-19 infections.
- Subjects :
- Male
Aging
medicine.medical_specialty
Epidemiology
Pneumonia, Viral
Type 2 diabetes
Comorbidity
Risk Assessment
Cohort Studies
Betacoronavirus
AcademicSubjects/MED00280
COVID-19 Testing
Sex Factors
Risk Factors
Internal medicine
medicine
Dementia
Humans
Mortality
Noncommunicable Diseases
Pandemics
Depression (differential diagnoses)
Aged
Preexisting Condition Coverage
business.industry
Clinical Laboratory Techniques
SARS-CoV-2
Age Factors
COVID-19
medicine.disease
United Kingdom
Hospitalization
Ageing
Cohort
Chronic Disease
AcademicSubjects/SCI00960
Female
Morbidity
Geriatrics and Gerontology
business
Coronavirus Infections
Kidney disease
Cohort study
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 1758535X and 10795006
- Database :
- OpenAIRE
- Journal :
- The Journals of Gerontology: Series A
- Accession number :
- edsair.doi.dedup.....6c1b0868621378b89cd995991a3accc3
- Full Text :
- https://doi.org/10.1093/gerona/glaa183