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Type-specific antiviral antibodies to genital human papillomavirus types in mothers and newborns

Type-specific antiviral antibodies to genital human papillomavirus types in mothers and newborns

Authors :
Andrea Geier
Reinhard Höpfl
Gernot Hudelist
Klaus Czerwenka
Kurt Heim
Birgit Volgger
A. Bergant
Nicole Concin
Neil D. Christensen
Hannes Szedenik
Source :
Reproductive sciences (Thousand Oaks, Calif.). 14(8)
Publication Year :
2007

Abstract

Type-specific antibodies to human papillomaviruses (HPVs) can be detected in most infected adult patients, and they have virus-neutralizing properties. However, there is a dearth of information on the seroprevalence of maternal and neonatal antibodies to HPV capsid antigens. Sera from 104 mothers, their newborns, and 3 twin pregnancies were analyzed by an enzyme-linked immunosorbent assay (ELISA) for the presence of specific IgG, IgM, and IgA antibodies to virus-like particles of HPV-6, -11, -16, -18, and -31. Maternal IgG positivity rates to HPV types 6, 11, 16, 18, and 31 were 23.1%, 2.9%, 8.7%, 5.8%, and 9.6%, respectively. Neonatal rates did not differ significantly, and individual IgG ELISA values of mothers and their infants and all paired twins showed a very high correlation. In contrast, nearly all IgM and IgA individual values in newborns were designated negative, whereas mothers' positivity rates ranged as high as 19.2%. Infants showed no HPV-related lesions at birth or at 4-year follow-up. Seven of 8 tested children lost IgG HPV antibodies in a follow-up examination. Similar anti-HPV IgG seropositivity in mothers and newborns and a lack of neonatal IgA and IgM together with twin and follow-up results indicate that neonatal IgG is not a sign of intrauterine HPV infection but, rather, maternofetal antibody transmission.

Details

ISSN :
19337205
Volume :
14
Issue :
8
Database :
OpenAIRE
Journal :
Reproductive sciences (Thousand Oaks, Calif.)
Accession number :
edsair.doi.dedup.....6c26908f2eae75f64d85b7674125b3f4