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Role of endogenous oxytocin in cardiac ischemic preconditioning
- Source :
- Regulatory Peptides. 167:86-90
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- The aim of the present study is to assess the role of endogenous oxytocin (OT) in cardioprotective effects of ischemic preconditioning (IPC) in anesthetized rat.Animals were divided into five groups: 1) ischemia-reperfusion (IR); (n=6), hearts were subjected to 25 min regional ischemia and 60 min reperfusion, 2) OT; (n=6), oxytocin was administered (0.03 μg/kg i.p) 10 min prior to ischemia, 3) IPC; (n=7), IPC was induced via a 5 min regional ischemia followed by 5 min of reperfusion before IR, 4) IPC+ATO (Atosiban); (n=6), atosiban (1.5 μg/kg i.p) was used as OT receptor selective antagonist in the beginning of IPC and 5) IR+ATO; (n=6), atosiban was injected 10 min prior to ischemia-reperfusion.In our experiment, Infarct size was decreased significantly in OT and IPC groups compared to IR (23 ± 1.5% and 19 ± 0.6% vs. 45 ± 2.9% in IR group, P0.05). Administration of atosiban in IPC+ATO group increased infarct size to 39 ± 0.9% in comparison with OT and IPC groups (P0.05). The use of OT and IPC prior to ischemia significantly declined ventricular arrhythmias severity in compared to IR group (1.2 ± 0.4 and 1 ± 0.5 respectively, vs. 4 ± 0.4 in IR group, P0.05). Blockade of OT receptor by atosiban abolished the cardiopreconditioning effects of IPC.This study shows that, in part, the cardioprotective effects of IPC can be induced by endogenous OT.
- Subjects :
- Male
medicine.medical_specialty
Cardiotonic Agents
Physiology
Clinical Biochemistry
Myocardial Infarction
Ischemia
Myocardial Reperfusion Injury
Endogeny
Oxytocin
medicine.disease_cause
Severity of Illness Index
Biochemistry
Cellular and Molecular Neuroscience
Hormone Antagonists
Vasotocin
Endocrinology
Internal medicine
parasitic diseases
medicine
Animals
cardiovascular diseases
Rats, Wistar
Receptor
business.industry
Hemodynamics
Antagonist
Arrhythmias, Cardiac
Heart
Atosiban
medicine.disease
Rats
Oxidative Stress
Ischemic Preconditioning, Myocardial
Ischemic preconditioning
business
Oxidative stress
medicine.drug
Subjects
Details
- ISSN :
- 01670115
- Volume :
- 167
- Database :
- OpenAIRE
- Journal :
- Regulatory Peptides
- Accession number :
- edsair.doi.dedup.....6c2c15c09f8dc43317dc0c4173dba8ae