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Sevoflurane Versus Desflurane on the Incidence of Postreperfusion Syndrome During Living Donor Liver Transplantation
- Source :
- Transplantation. 100:600-606
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- Background Various interventions to reduce postreperfusion syndrome during liver transplantation have been explored, but the effect of volatile anesthetics used during liver transplantation on the incidence of postreperfusion syndrome has not been evaluated. A randomized controlled trial was performed to compare the incidence of postreperfusion syndrome between 2 commonly used volatile anesthetics, sevoflurane and desflurane. Methods Sixty-two adult liver recipients scheduled for living-donor liver transplantation were randomized to receive either sevoflurane or desflurane for general anesthesia. The incidence of postreperfusion syndrome, use of vasoactive drugs, and postoperative course were compared. The risk factors associated with postreperfusion syndrome were also analyzed. Results There was significantly less postreperfusion syndrome in the sevoflurane group compared to the desflurane group (38.7% vs 77.4%, P = 0.004) and less epinephrine was required in the sevoflurane group than the desflurane group (19.4% vs 45.2%, P = 0.030). Postoperative intensive care unit and hospital length of stay and postoperative course were similar between the groups. Multivariate analysis identified desflurane (compared to sevoflurane) as the only risk factor (odds ratio 7.314, P = 0.001) for reperfusion syndrome. Conclusions When using volatile anesthetics for elective living donor liver transplantation, sevoflurane seems to be a better option than desflurane for reducing the incidence of postreperfusion syndrome.
- Subjects :
- Adult
Male
Methyl Ethers
Time Factors
medicine.medical_treatment
Liver transplantation
Sevoflurane
law.invention
03 medical and health sciences
Desflurane
Postoperative Complications
0302 clinical medicine
Randomized controlled trial
Risk Factors
030202 anesthesiology
law
Republic of Korea
Living Donors
medicine
Humans
Prospective Studies
Risk factor
Prospective cohort study
Transplantation
Isoflurane
business.industry
Patient Selection
Syndrome
Odds ratio
Length of Stay
Middle Aged
Intensive care unit
Liver Transplantation
Intensive Care Units
Treatment Outcome
Anesthesia
Anesthetics, Inhalation
Female
030211 gastroenterology & hepatology
business
medicine.drug
Subjects
Details
- ISSN :
- 00411337
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Transplantation
- Accession number :
- edsair.doi.dedup.....6c30111d4d4e15b2475a6ea7c01aa619