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Definition of Synchronous Oligometastatic Non-Small Cell Lung Cancer-A Consensus Report
- Source :
- Journal of Thoracic Oncology, 14(12), 2109-2119. International Association for the Study of Lung Cancer, Journal of Thoracic Oncology, 14(12), 2109-2119. ELSEVIER SCIENCE INC, Journal of Thoracic Oncology, 14(12), 2109-2119. Elsevier Science, Dingemans, A-M C, Hendriks, L E L, Berghmans, T, Levy, A, Hasan, B, Faivre-Finn, C, Giaj-Levra, M, Giaj-Levra, N, Girard, N, Greillier, L, Lantuéjoul, S, Edwards, J, O'Brien, M, Reck, M, Smit, E F, Van Schil, P, Postmus, P E, Ramella, S, Lievens, Y, Gaga, M, Peled, N, Scagliotti, G V, Senan, S, Paz-Ares, L, Guckenberger, M, McDonald, F, Ekman, S, Cufer, T, Gietema, H, Infante, M, Dziadziuszko, R, Peters, S, Porta, R R, Vansteenkiste, J, Dooms, C, de Ruysscher, D, Besse, B & Novello, S 2019, ' Definition of synchronous oligo-metastatic non-small cell lung cancer-a consensus report ', Journal of Thoracic Oncology, vol. 14, no. 12, pp. 2109-2119 . https://doi.org/10.1016/j.jtho.2019.07.025, J Thorac Dis, Journal of thoracic oncology
- Publication Year :
- 2019
-
Abstract
- Introduction: Improved outcome has been shown in patients with synchronous oligometastatic (sOM) NSCLC when treated with radical intent. As a uniform definition of sOM NSCLC is lacking, we developed a definition and diagnostic criteria by a consensus process.Methods: A pan-European multidisciplinary consensus group was established. Consensus questions were built on the basis of current controversies, and definitions were extracted from a survey, cases and a systematic review. This statement was formulated during a consensus meeting.Results: It was determined that definition of sOM NSCLC is relevant when a radical treatment that may modify the disease course (leading to long-term disease control) is technically feasible for all tumor sites with acceptable toxicity. On the basis of the review, a maximum of five metastases and three organs was proposed. Mediastinal lymph node involvement was not counted as a metastatic site. Fludeoxyglucose F 18 positron emission tomography-computed tomography and brain imaging were considered mandatory. A dedicated liver magnetic resonance imaging scan was advised for a solitary liver metastasis, and thoracoscopy and biopsies of distant ipsilateral pleural sites were recommended for a solitary pleural metastasis. For mediastinal staging, fludeoxyglucose F 18 positron emission tomography-computed tomography was deemed the minimum requirement, with pathological confirmation recommended if this influences the treatment strategy. Biopsy of a solitary metastatic location was mandated unless the multidisciplinary team is of the opinion that the risks outweigh the benefits.Conclusion: A multidisciplinary consensus statement on the definition and staging of sOM NSCLC has been formulated. This statement will help to standardize inclusion criteria in future clinical trials. (C) 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
Male
medicine.medical_specialty
ADRENAL METASTASES
Fludeoxyglucose F-18
Consensus
Lung Neoplasms
Staging
Non-small cell lung cancer
consensus definition
oligometastatic disease
staging
MULTICENTER
NSCLC
GUIDELINES
THERAPY
DISEASE
Metastasis
03 medical and health sciences
0302 clinical medicine
PROGNOSTIC-FACTORS
Neuroimaging
SDG 3 - Good Health and Well-being
Carcinoma, Non-Small-Cell Lung
Biopsy
Thoracoscopy
Medicine
Humans
Oligometastatic disease
Lung cancer
Neoplasm Staging
Consensus definition
OUTCOMES
medicine.diagnostic_test
business.industry
medicine.disease
Clinical trial
Editorial Commentary
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Mediastinal lymph node
PHASE-II
Female
Radiology
Human medicine
RADICAL TREATMENT
business
Subjects
Details
- ISSN :
- 15560864
- Volume :
- 14
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of Thoracic Oncology
- Accession number :
- edsair.doi.dedup.....6c4946a26c07496dd8b5b6717d8b687c