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Mediators Involved in the Immunomodulatory Effects of Apoptotic Cells
- Source :
- Transplantation, Transplantation, Lippincott, Williams & Wilkins, 2007, 84 (1 Suppl), pp.S31-4. ⟨10.1097/01.tp.0000269113.59857.d6⟩
- Publication Year :
- 2007
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2007.
-
Abstract
- International audience; Immunomodulatory properties are attributed to apoptotic cells. These properties have been used to modulate allogeneic immune responses in experimental transplantation settings. In independent studies, apoptotic cell infusion has been shown to favor hematopoietic cell engraftment, to increase heart graft survival, and to delay the lethal onset of graft-versus-host disease (GVHD). The goal of this review was to discuss how apoptotic cell infusion interferes with graft rejection or host rejection (i.e., GVHD) and to focus on the potential mediators or "perpetuators" involved in apoptotic cell-induced immunomodulation. Particular emphasis on apoptotic cell phagocytosis, transforming growth factor (TGF)-beta secretion, and regulatory T cell induction was performed. Stimulating "naturally" immunosuppressive molecules (i.e., TGF-beta) or immunomodulatory cells ("alternatively-activated" macrophages, certain dendritic cell subsets, or regulatory T cells) in a physiological manner by using apoptotic cell infusion can be a promising way to induce tolerance.
- Subjects :
- TGF-β
MESH: Immune Tolerance
[SDV.IMM] Life Sciences [q-bio]/Immunology
Transcription, Genetic
Cell Transplantation
Regulatory T cell
Cell
Apoptosis
Biology
Article
regulatory T cells
Immune tolerance
03 medical and health sciences
0302 clinical medicine
Immune system
Transforming Growth Factor beta
Immune Tolerance
medicine
Animals
MESH: Animals
Secretion
dendritic cells
MESH: Transforming Growth Factor beta
030304 developmental biology
0303 health sciences
Transplantation
MESH: Apoptosis
MESH: Transcription, Genetic
apoptotic cells
Transforming growth factor beta
macrophages
3. Good health
MESH: Cell Transplantation
surgical procedures, operative
medicine.anatomical_structure
Immunology
biology.protein
[SDV.IMM]Life Sciences [q-bio]/Immunology
030215 immunology
Subjects
Details
- ISSN :
- 00411337 and 15346080
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- Transplantation
- Accession number :
- edsair.doi.dedup.....6c49c18789ab43995596339b4904a750