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First trimester, second trimester, and integrated screening for Down's syndrome in China

Authors :
Ying Xu
Shao-Hua Tang
Tong-kun Shi
Zheng-you Miao
Qinhao Song
Xia Liu
Source :
Journal of Medical Screening. 19:68-71
Publication Year :
2012
Publisher :
SAGE Publications, 2012.

Abstract

Objective To compare the effectiveness of first trimester, second trimester, and integrated screening for Down's syndrome. Setting Two prenatal diagnosis centres in China. Methods A total of 11,966 pregnant women (≥18 years) were screened over 21 months. First trimester screening (11–13 weeks) comprised measurement of serum free beta-human chorionic gonadotrophin (β-hCG) and pregnancy-associated protein-A concentrations, and fetal nuchal translucency thickness. Second trimester screening (15–20 weeks) comprised measurement of β-hCG and alpha fetoprotein concentrations. Computer software was used to calculate the risk of carrying a Down's syndrome fetus. Results The overall incidence of Down's syndrome was 0.2% (23/11,966). When the false-positive rate was fixed at 5%, detection rates for first trimester, second trimester, and integrated screening were 73.9%, 69.6%, and 82.6%, respectively. When the false-positive rate was fixed at 3%, detection/sensitivity rates for first trimester, second trimester, and integrated screening were 65.2%, 56.5%, and 73.9%, respectively. Conclusions These findings suggest that integrated screening was the most effective means of screening for Down's syndrome in a Chinese population.

Details

ISSN :
14755793 and 09691413
Volume :
19
Database :
OpenAIRE
Journal :
Journal of Medical Screening
Accession number :
edsair.doi.dedup.....6c5023067273a9589e31b7428c2f3698