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Total Synthesis of (+)-Peloruside A
- Source :
- ChemInform. 36
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- [reaction: see text] A total synthesis of (+)-peloruside A has been successfully achieved. The strategy was highlighted by a late stage aldol coupling of two complex fragments followed by an intramolecular hemi-ketal cyclization, a MOM group participated epoxide ring fragmentation reaction, and a highly selective methylation. This convergent route allows access to rationally designed analogues.
- Subjects :
- Molecular Structure
Stereochemistry
Organic Chemistry
Total synthesis
Epoxide
Stereoisomerism
General Medicine
Methylation
Bridged Bicyclo Compounds, Heterocyclic
Ring (chemistry)
Biochemistry
Porifera
Lactones
chemistry.chemical_compound
chemistry
Aldol reaction
Fragmentation (mass spectrometry)
Cyclization
Intramolecular force
Animals
Peloruside A
Physical and Theoretical Chemistry
Subjects
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi.dedup.....6c83c3be79584e59b1b97226de4ebde2