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Follicular CD4 T Helper Cells As a Major HIV Reservoir Compartment: A Molecular Perspective
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 9 (2018)
- Publication Year :
- 2018
- Publisher :
- Frontiers Media SA, 2018.
-
Abstract
- Effective antiretroviral therapy (ART) has prevented the progression to AIDS and reduced HIV-related morbidities and mortality for the majority of infected individuals. However, a lifelong administration of ART is necessary, placing an inordinate burden on individuals and public health systems. Therefore, discovering therapeutic regimens able to eradicate or functionally cure HIV infection is of great importance. ART interruption leads to viral rebound highlighting the establishment and maintenance of a latent viral reservoir compartment even under long-term treatment. Follicular helper CD4 T cells (TFH) have been reported as a major cell compartment contributing to viral persistence, consequent to their susceptibility to infection and ability to release replication-competent new virions. Here, we discuss the molecular profiles and potential mechanisms that support the role of TFH cells as one of the major HIV reservoirs.
- Subjects :
- lcsh:Immunologic diseases. Allergy
0301 basic medicine
Viral rebound
Cell
Immunology
Human immunodeficiency virus (HIV)
HIV Infections
Virus Replication
medicine.disease_cause
03 medical and health sciences
Acquired immunodeficiency syndrome (AIDS)
lymph nodes
Follicular phase
Humans
Medicine
Compartment (development)
Immunology and Allergy
TFH cell
business.industry
HIV
T-Lymphocytes, Helper-Inducer
medicine.disease
Antiretroviral therapy
cure
Virus Latency
3. Good health
030104 developmental biology
medicine.anatomical_structure
Anti-Retroviral Agents
Perspective
gene expression
Disease Progression
HIV-1
lcsh:RC581-607
business
Viral persistence
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....6c83dd16bd6e804943c05c43d8ffdf72
- Full Text :
- https://doi.org/10.3389/fimmu.2018.00895