Osmium tetroxide, N ,N ,N' ,N' -tetramethylethylendiamine A new probe of DNA structure in the cell

It was shown that the complex of osmium tetroxide with N,N,N',N'-tetramethylethylendiamine can be applied as a probe of DNA structure in the cell. This probe site-specifically recognized structural distortions at the B-Z junctions in plasmids pRW751 and pPK1 (containing (dC-dG)n. segments) in E. coli cells.