Back to Search
Start Over
Secretory leukocyte protease inhibitor and progranulin as possible regulators of cervical remodeling in pregnancy
Secretory leukocyte protease inhibitor and progranulin as possible regulators of cervical remodeling in pregnancy
- Source :
- Journal of Reproductive Immunology. 143:103241
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Secretory leukocyte protease inhibitor (SLPI) and progranulin (PGRN) are secretory proteins with an anti-inflammatory property. Their involvement in cervical remodeling in pregnant uterus is not yet elucidated. Thus, this study aimed to explore the significance of SLPI and PGRN in the maintenance of pregnancy by investigating the factors associated with their expression levels at the cervix. Concentrations of SLPI and PGRN proteins were measured in cervical mucus samples collected from asymptomatic pregnant women at 24-26 weeks of gestation (n = 166). The concentrations of those molecules were analyzed with clinical parameters related to risk for preterm delivery (PD). In pregnant mice, we evaluated the effect of lipopolysaccharide-induced inflammation and progesterone effect modulation on cervical mRNA expression of SLPI and PGRN. The cervical PGRN level was significantly lower in women with short cervix (
- Subjects :
- Adult
Lipopolysaccharides
0301 basic medicine
medicine.medical_specialty
Immunology
Inflammation
Cervix Uteri
Proinflammatory cytokine
Progesterone Antagonist
Mice
Young Adult
03 medical and health sciences
Hormone Antagonists
Progranulins
0302 clinical medicine
Downregulation and upregulation
Pregnancy
Internal medicine
medicine
Animals
Humans
Immunology and Allergy
Secretory Leukocyte Peptidase Inhibitor
Cervix
Progesterone
030219 obstetrics & reproductive medicine
business.industry
Obstetrics and Gynecology
Mifepristone
Up-Regulation
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
Secretory protein
Endocrinology
Reproductive Medicine
Pregnancy Trimester, Second
Models, Animal
Cervix Mucus
Premature Birth
Female
medicine.symptom
business
Maternal Age
SLPI
medicine.drug
Subjects
Details
- ISSN :
- 01650378
- Volume :
- 143
- Database :
- OpenAIRE
- Journal :
- Journal of Reproductive Immunology
- Accession number :
- edsair.doi.dedup.....6c98c8a2f8f84f6ef8ee03c4d20f30ba
- Full Text :
- https://doi.org/10.1016/j.jri.2020.103241