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Secretory leukocyte protease inhibitor and progranulin as possible regulators of cervical remodeling in pregnancy

Secretory leukocyte protease inhibitor and progranulin as possible regulators of cervical remodeling in pregnancy

Authors :
Yutaka Osuga
Takeshi Nagamatsu
Ayumi Taguchi
Kei Kawana
Tatsuya Fujii
Seisuke Sayama
Takayuki Iriyama
Naoya Akiba
Taiki Samejima
Tomoyuki Fujii
Keiichi Kumasawa
Source :
Journal of Reproductive Immunology. 143:103241
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

Secretory leukocyte protease inhibitor (SLPI) and progranulin (PGRN) are secretory proteins with an anti-inflammatory property. Their involvement in cervical remodeling in pregnant uterus is not yet elucidated. Thus, this study aimed to explore the significance of SLPI and PGRN in the maintenance of pregnancy by investigating the factors associated with their expression levels at the cervix. Concentrations of SLPI and PGRN proteins were measured in cervical mucus samples collected from asymptomatic pregnant women at 24-26 weeks of gestation (n = 166). The concentrations of those molecules were analyzed with clinical parameters related to risk for preterm delivery (PD). In pregnant mice, we evaluated the effect of lipopolysaccharide-induced inflammation and progesterone effect modulation on cervical mRNA expression of SLPI and PGRN. The cervical PGRN level was significantly lower in women with short cervix (

Details

ISSN :
01650378
Volume :
143
Database :
OpenAIRE
Journal :
Journal of Reproductive Immunology
Accession number :
edsair.doi.dedup.....6c98c8a2f8f84f6ef8ee03c4d20f30ba
Full Text :
https://doi.org/10.1016/j.jri.2020.103241