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H19 Overexpression Induces Resistance to 1,25(OH)2D3 by Targeting VDR Through miR-675-5p in Colon Cancer Cells
- Source :
- Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 3, Pp 226-236 (2017), Neoplasia (New York, N.Y.)
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The long noncoding (lnc) RNA H19 was involved in the tumorigenesis of many types of cancer. However, the role of H19 in the tumorigenesis of colon cancer has not been fully illustrated. Recent studies suggested a potential relationship between H19 and vitamin D receptor (VDR) signaling. Considering the pivotal role of VDR signaling in the colon epithelium both physiologically and pathologically, the correlation between H19 and VDR signaling may have an important role in the development of colon cancer. In this study, the correlation between H19 and vitamin D receptor (VDR) signaling and the underlying mechanisms in colon cancer were investigated both in vitro and in vivo. The results suggested that VDR signaling was able to inhibit the expression of H19 through regulating C-Myc/Mad-1 network. H19, on the other hand, was able to inhibit the expression of VDR through micro RNA 675-5p (miR-675-5p). Furthermore, H19 overexpression induced resistance to the treatment with 1,25(OH)2D3 both in vitro and in vivo. Together, these results suggested that H19 overexpression might be one of the mechanisms underlying the development of resistance to the treatment with 1,25(OH)2D3 in the advanced stage of colon cancer.
- Subjects :
- 0301 basic medicine
Original article
Cancer Research
medicine.medical_specialty
Colorectal cancer
Drug Resistance
Gene Expression
Cell Cycle Proteins
Biology
medicine.disease_cause
lcsh:RC254-282
Calcitriol receptor
Proto-Oncogene Proteins c-myc
Mice
03 medical and health sciences
0302 clinical medicine
Calcitriol
Cell Movement
RNA interference
Cell Line, Tumor
Internal medicine
microRNA
medicine
Animals
Humans
Gene Regulatory Networks
Receptor
Cell Proliferation
Regulation of gene expression
Nuclear Proteins
Cancer
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Xenograft Model Antitumor Assays
female genital diseases and pregnancy complications
Gene Expression Regulation, Neoplastic
Disease Models, Animal
MicroRNAs
030104 developmental biology
Endocrinology
030220 oncology & carcinogenesis
Colonic Neoplasms
embryonic structures
Cancer research
Receptors, Calcitriol
RNA Interference
RNA, Long Noncoding
Carcinogenesis
Signal Transduction
Subjects
Details
- ISSN :
- 14765586
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Neoplasia
- Accession number :
- edsair.doi.dedup.....6ca968ce9149df0124576523f660e194